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iodinated glycerol
secretolytic agent; RN given refers to cpd without iodine locant
Also Known As:
Mucantil; Organidin; glycerol, iodinated; iodopropylidene glycerol
Networked:
18
relevant articles (
3
outcomes,
10
trials/studies)
Relationship Network
Bio-Agent Context: Research Results
Organic Chemicals: 133
Alcohols: 595
Sugar Alcohols: 143
Triose Sugar Alcohols: 4
Glycerol: 4398
iodinated glycerol: 18
Carbohydrates: 22023
Sugar Alcohols: 143
Triose Sugar Alcohols: 4
Glycerol: 4398
iodinated glycerol: 18
Related Diseases
1.
Chronic Bronchitis
09/01/1993 - "
Treatment of stable chronic bronchitis with iodinated glycerol: a double-blind, placebo-controlled trial.
"
02/01/1996 - "
Iodinated glycerol has no effect on pulmonary function, symptom score, or sputum properties in patients with stable chronic bronchitis.
"
02/01/1996 - "
It has been reported that therapy with iodinated glycerol (IG) can improve the quality of life for patients with chronic bronchitis.
"
09/01/1993 - "
In conclusion, this study demonstrates that iodinated glycerol, 60-mg tablets given in a total daily dose of 240 mg, is safe and effective therapy for reducing symptoms in patients with stable, chronic bronchitis.
"
09/01/1993 - "
In a double-blind trial, 29 patients were treated for stable, chronic bronchitis with iodinated glycerol (Organidin, 60 mg four times daily; n = 16) or placebo (n = 13).
"
2.
Cough
09/01/1993 - "
In this set of patients, treatment with iodinated glycerol was associated with statistically significant (P < 0.05) and/or positive trend (P < 0.1) toward improvement in cough frequency, cough severity, difficulty in raising sputum, sputum thickness, sputum stickiness, forced expiratory flow at FVC25%-75%, cell concentration in sputum, and several measures of physician assessment of patient condition.
"
01/01/1990 - "
Cough frequency, cough severity, chest discomfort, patients' ease in bringing up sputum, patients' overall condition, and a derived subject global assessment were significantly (p less than 0.05) improved by iodinated glycerol as compared with placebo within eight weeks of treatment.
"
01/01/1990 - "
A total of 361 patients (180 to iodinated glycerol and 181 to placebo) who complained of cough and difficulty bringing up sputum entered the eight-week study.
"
01/01/1986 - "
The cough syrups used in the study were the aforementioned formulation (CM), promethazine hydrochloride with codeine (PH), and iodinated glycerol with codeine phosphate (IG).
"
3.
Carcinogenesis
10/01/1993 - "
Critique of the toxicology and carcinogenesis studies of iodinated glycerol in F344/N rats and B6C3F1 mice.
"
03/01/1990 - "
NTP Toxicology and Carcinogenesis Studies of Iodinated Glycerol (Organidin(R).) (CAS No. 5634-39-9) in F344/N Rats and B6C3F1 Mice (Gavage Studies).
"
03/01/1990 - "
Toxicology and carcinogenesis studies of iodinated glycerol (Organidin(R)., a complex mixture prepared by the reaction of iodine with glycerol and found to contain 33% 3-iodo-1,2-propanediol as the major component) were conducted because of human exposure to iodinated glycerol as an expectorant and its possible relationship to the formation of alkyl iodides, e.g., methyl iodide, a suspected animal carcinogen.
"
4.
Lymphoma (Lymphomas)
12/05/1997 - "
Previous studies have shown that iodinated glycerol azeo is positive in a number of in vitro mutagenicity assays including the Ames assay (TA100; TA1535), mouse lymphoma assay, Chinese hamster ovary (cytogenetic) assay and in one in vivo study, the sex-linked-recessive-lethal assay in Drosophila.
"
03/01/1990 - "
Genetic toxicology studies were conducted with iodinated glycerol in Salmonella typhimurium, mouse L5178Y lymphoma cells, Chinese hamster ovary (CHO) cells, and B6C3F1 mice (in vivo bone marrow micronucleus test).
"
03/01/1990 - "
Iodinated glycerol increased the number of trifluorothymidine-resistant cells in mouse lymphoma L5178Y/TK± assay in the absence of exogenous metabolic activation; it was not tested with activation.
"
5.
Leukemia
03/01/1990 - "
Conclusions: Under the conditions of these 2-year gavage studies, there was some evidence of carcinogenic activity for male F344/N rats administered iodinated glycerol, as indicated by increased incidences of mononuclear cell leukemia and follicular cell carcinomas of the thyroid gland.
"
01/01/1992 - "
Based on results from the short-term leukemia transplant model, data from 2-year carcinogenicity studies, and structure-activity considerations, exposure to iodinated glycerol and trichlorfon was more strongly associated with the expression of leukemia than exposure to acetaminophen.
"
01/01/1992 - "
Sixty-day bioassays of iodinated glycerol, trichlorfon, and acetaminophen were conducted using a leukemia transplant model in 6- to 8-week-old F344 rats to investigate the potential of these chemicals to affect tumor progression.
"
01/01/1992 - "
The effects of iodinated glycerol, trichlorfon, and acetaminophen on tumor progression in a Fischer rat leukemia transplant model.
"
Related Drugs and Biologics
1.
iodinated glycerol
2.
Expectorants (Mucolytics)
3.
Tablets
4.
Iodine
5.
Iodides
6.
Complex Mixtures
7.
Propylene Glycol (1,2 Propanediol)
8.
Ethylene Dibromide (1,2 Dibromoethane)
9.
Trichlorfon (Metrifonate)
10.
Promethazine (Promet)
Related Therapies and Procedures
1.
Therapeutics
2.
Home Nursing (Nursing, Home)