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methylmalonyl-coenzyme A (methylmalonyl CoA)

Also Known As:
methylmalonyl CoA; coenzyme A, methylmalonyl-
Networked: 50 relevant articles (0 outcomes, 3 trials/studies)

Bio-Agent Context: Research Results

Experts

1. Chandler, Randy J: 3 articles (09/2021 - 09/2006)
2. Venditti, Charles P: 3 articles (09/2021 - 09/2006)
3. Manoli, Irini: 2 articles (09/2021 - 08/2011)
4. Armstrong, Allison J: 2 articles (01/2021 - 01/2020)
5. Figler, Robert A: 2 articles (01/2021 - 01/2020)
6. Hoang, Stephen A: 2 articles (01/2021 - 01/2020)
7. Wamhoff, Brian R: 2 articles (01/2021 - 01/2020)
8. Chapman, Kimberly A: 2 articles (01/2020 - 01/2018)
9. Cane, David E: 2 articles (10/2010 - 10/2010)
10. Valenzano, Chiara R: 2 articles (10/2010 - 10/2010)

Related Diseases

1. Methylmalonic acidemia
2. Tuberculosis (Tuberculoses)
3. Dehydration (Water Stress)
10/27/2010 - "Similarly, incubation of a mixture of (2S,3R)-2-methyl-3-hydroxypentanoyl-N-acetylcysteamine thioester (2b-SNAC), methylmalonyl-CoA, and NADPH with DEBS [KS6][AT6], DEBS ACP6, and TYLS KR1 gave anti-(2R,3R)-6-ACP that underwent syn dehydration catalyzed by DEBS DH4 to give (4R,5R)-(E)-2,4-dimethyl-5-hydroxy-hept-2-enoyl-ACP (7-ACP). "
10/27/2010 - "Incubation of a mixture of propionyl-SNAC (4), methylmalonyl-CoA, and NADPH with the DEBS β-ketoacyl synthase-acyl transferase [KS6][AT6] didomain, DEBS ACP6, and the ketoreductase domain from tylactone synthase module 1 (TYLS KR1) generated in situ anti-2a-ACP that underwent DH4-catalyzed syn dehydration to give 3-ACP. "
10/27/2010 - "The recombinant dehydratase domain from NANS module 2, NANS DH2, was shown to catalyze the formation of an (E)-double bond by syn-dehydration of the ACP-bound substrate anti-(2R,3R,4S,5R)-2,4-dimethyl-3,5-dihydroxyheptanoyl-ACP6 (4), generated in situ by incubation of (2S,3R)-2-methyl-3-hydroxypentanoyl-SNAC (5), methylmalonyl-CoA, and NADPH with the recombinant [KS6][AT6] didomain and ACP6 from DEBS module 6 along with the ketoreductase from the tylactone synthase module 1 (TYLS KR1). "
01/01/2016 - "Enzymatic activity studies showed that ThgI catalyses the condensation of acetyl-CoA and methylmalonyl-CoA to 2-methylacetoacetyl-CoA (MAA-CoA), ThgK catalyses NADPH-dependent reduction of MAA-CoA to 3-hydroxy-2-methylbutyryl-CoA (HMB-CoA) and ThgH catalyses the dehydration of HMB-CoA to angelyl-CoA (AN-CoA). "
4. Propionic Acidemia
5. Vitamin B 12 Deficiency (Vitamin B12 Deficiency)

Related Drugs and Biologics

1. Coenzyme A (CoA)
2. NADP (NADPH)
3. Acetyl Coenzyme A (Acetyl-CoA)
4. Biomarkers (Surrogate Marker)
5. Vaccines
6. Complement C3 (C3 Complement)
7. 12- (4'- azido- 2'- nitrophenoxy)dodecanoyl- coenzyme A
8. 2-methylacetoacetyl-coenzyme A
9. Propionyl-Coenzyme A Carboxylase (Propionyl CoA Carboxylase)
10. propionyl-coenzyme A (propionyl-CoA)