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mepindolol
2-methyl deriv of pindolol; RN given refers to parent cpd; structure
Also Known As:
1-(isopropylamino)-3-(2-methylindol-4-yloxy)-2-propanol sulfate; Corindolan; LF 17-895; SH E 222; bis(4-(2-hydroxy-3-isopropylaminopropoxy)-2-methylindol) sulfate; mepindolol sulfate (2:1)
Networked:
26
relevant articles (
4
outcomes,
8
trials/studies)
Relationship Network
Bio-Agent Context: Research Results
Organic Chemicals: 133
Amines: 4871
Amino Alcohols: 20
Propanolamines: 4
Phenoxypropanolamines: 1
Pindolol: 735
mepindolol: 26
Alcohols: 595
Amino Alcohols: 20
Propanolamines: 4
Phenoxypropanolamines: 1
Pindolol: 735
mepindolol: 26
Propanols: 3
Propanolamines: 4
Phenoxypropanolamines: 1
Pindolol: 735
mepindolol: 26
Related Diseases
1.
Infarction (Infarctions)
05/01/1985 - "
This study was designed to assess whether or not mepindolol is effective in reducing infarct size.
"
02/01/1985 - "
This study was designed to assess whether mepindolol administration is effective in reducing infarct size.
"
05/01/1985 - "
Infarct size calculated by this method was 30.2 +/- 4.8% of left ventricle in 21 control animals and 18.2 +/- 4.2% in 28 treated rats (p less than 0.05), indicating that, as for the acute necrosis, the extent of scar development after coronary artery occlusion can be reduced by mepindolol.
"
2.
Hypertension (High Blood Pressure)
01/01/1990 - "
The treatment of mild hypertension with mepindolol: a chronobiological evaluation.
"
11/01/1984 - "
The effect on bioperiodic parameters of hypertension elicited by the beta-blocking agent mepindolol, administered as a single dose of 10 mg at 8 a.m.
"
08/26/1983 - "
[Treatment of hypertension with the beta blocker Corindolan.
"
01/01/1983 - "
These results point to the efficacy of mepindolol in the treatment of hypertension of chronic renal disease.
"
01/01/1983 - "
The efficacy of mepindolol in the control of blood pressure during 24 hours was investigated in nine patients with hypertension accompanying chronic renal disease.
"
3.
Chronic Renal Insufficiency
01/01/1983 - "
These results point to the efficacy of mepindolol in the treatment of hypertension of chronic renal disease.
"
01/01/1983 - "
The efficacy of mepindolol in the control of blood pressure during 24 hours was investigated in nine patients with hypertension accompanying chronic renal disease.
"
01/01/1983 - "
The 24-hour control of blood pressure in hypertension of chronic renal disease with mepindolol.
"
4.
Coronary Disease (Coronary Heart Disease)
10/20/1979 - "
The effect of mepindolol-sulfate (2 x 2.5 mg) was tested in 20 patients with coronary heart disease in a controlled study against placebo resp.
"
11/01/1989 - "
A new transdermal system (BIO TSD) containing the beta-adrenergic blocker mepindolol was assessed in a placebo controlled clinical trial in 12 patients with coronary heart disease.
"
10/20/1979 - "
[A double blind cross-over study with mepindolol-sulfate in patients with coronary heart disease (author's transl)].
"
01/01/1978 - "
[Hemodynamics in patients with coronary heart disease under conditions of physical exercise before and after mepindolol-sulfate (author's transl)].
"
08/01/1990 - "
A new transdermal beta-blocker containing system (Mepindolol BIO TSD) was compared in a placebo controlled cross over trial with a transdermal nitrate system in 14 patients suffering from coronary heart disease with stable angina pectoris.
"
5.
Essential Hypertension
11/01/1989 - "
In the present study, it could be demonstrated that transdermal monotherapy (BIO TSD) with a beta-blocker (20 mg mepindolol) in patients with essential hypertension led to an effective 24 h blood pressure lowering effect within 1 week (160.1 +/- 6.1 mmHg/95.8 +/- 8.3 mmHg vs. 136.8 +/- 7.2 mmHg/84.3 +/- 5.0 mmHg; p less than 0.05).
"
07/01/1988 - "
In our study, we demonstrated that transdermal application of a beta-blocker (20 mg mepindolol) in patients with essential hypertension led to effective blood pressure lowering effect within 1 week (160.1 +/- 6.1 mm Hg/95.8 +/- 8.3 mm Hg vs 136.8 +/- 7.2 mm Hg/84.3 +/- 5.0 mm Hg; P less than 0.05).
"
11/01/1982 - "
The results show that mepindolol, given as a single oral dose of 5 mg, is an effective agent in the treatment of mild to moderate essential hypertension.
"
11/01/1982 - "
Multicenter evaluation of mepindolol and of mepindolol plus hydrochlorothiazide in essential hypertension.
"
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1.
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2.
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3.
Nitrendipine
4.
Enalapril
5.
Antihypertensive Agents (Antihypertensives)
6.
Angiotensin-Converting Enzyme Inhibitors (ACE Inhibitors)
7.
Sulfates (Sulfates, Inorganic)
8.
Nitrates
9.
Propranolol (Inderal)
10.
Proteins (Proteins, Gene)
Related Therapies and Procedures
1.
Therapeutics