lycorine

01/01/2019 - "Meanwhile, an in vivo study revealed that lycorine inhibited tumor growth and induced apoptosis in a HepG2 xenograft mouse model in association with ROCK1 activation. "
05/01/2007 - "To determine whether lycorine has an anti-tumor effect in vivo, a series of experiments were carried out in this study. "
01/01/2024 - "Lycorine also showed significant suppressive effects in tumor-bearing mice. "
11/01/2023 - "Additionally, lycorine effectively suppressed tumor growth in mouse xenograft models without obvious toxicity. "
12/01/2022 - "Xenograft mouse experiments indicated that when lycorine was injected through the tail vein, HeLa tumor growth was inhibited. "

01/01/2022 - "Lycorine is a drug with pro-apoptotic ability and anti-fibrosis potential. "
01/01/2020 - "At the 2-month follow-up, both bufalin and lycorine led to significantly reduced cardiac fibrosis. "
01/01/2020 - "We identified the molecules bufalin and lycorine as drug candidates for therapeutic applications in cardiac fibrosis and diastolic dysfunction."
12/01/2021 - "Lycorine ameliorates isoproterenol-induced cardiac dysfunction mainly via inhibiting inflammation, fibrosis, oxidative stress and apoptosis."
12/01/2021 - "Overall, our findings demonstrate that lycorine protects against cardiac dysfunction induced by isoproterenol by inhibiting inflammation, fibrosis, oxidative stress, and apoptosis."

06/20/2015 - "Lycorine inhibited both growth and metastasis in multiple organs (liver, lung, kidney, spleen and bone) in vivo and improved mice survival. "
05/01/2021 - "Lycorine also reduced lung metastasis of CRC in vivo. "
05/01/2021 - "The mouse CRC lung metastasis model was established and was used to detect the effect of lycorine on CRC in vivo. "
05/01/2021 - "However, the effects and the detailed mechanism of lycorine against metastasis of CRC remains unclear. "
01/01/2020 - "In addition, orthotopic implantation model of 143B OS cells further confirmed that lycorine suppressed OS growth and lung metastasis in vivo. "

06/01/2023 - "Alleviating effect of lycorine on CFA‑induced arthritic pain via inhibition of spinal inflammation and oxidative stress."
09/01/2022 - "Literature searches in electronic databases, such as Web of Science, Science Direct, PubMed, Google Scholar, and Scopus, were performed using 'Lycorine', 'Amaryllidaceae', 'Pharmacology', 'Pharmacokinetics', 'Anti-inflammation', 'Autophagy', 'Apoptosis', 'Anti-microbial and anti-parasitic', 'Antitumor', 'Organ protection', and 'Sepsis' as keywords, the correlated literature was extracted and conducted from the databases mentioned above. "
03/18/2022 - "Moreover, lycorine ameliorated hepatic inflammation by preventing the rise of inflammatory cytokines. "
12/01/2021 - "Lycorine ameliorates isoproterenol-induced cardiac dysfunction mainly via inhibiting inflammation, fibrosis, oxidative stress and apoptosis."
12/01/2021 - "Overall, our findings demonstrate that lycorine protects against cardiac dysfunction induced by isoproterenol by inhibiting inflammation, fibrosis, oxidative stress, and apoptosis."

06/01/2021 - "We investigated the direct-inhibiting action of lycorine on CoV's RdRp, as potential treatment for emerging CoV infections. "
01/01/2020 - "Additionally, we found that lycorine acts post-infection according to time-of-addition assay, and inhibits RdRp activity. "
01/01/2020 - "Due to its potency and ability to target ZIKV infection in vivo and in vitro, lycorine might offer promising therapeutic possibilities for combatting ZIKV infections in the future."
01/01/2019 - "Three groups were designed: mock infection group (M), virus infection group (V), and virus infection and lycorine-treated after virus infection group (L). "
01/01/2019 - "Tandem mass tag-based quantitative proteomic analysis of lycorine treatment in highly pathogenic avian influenza H5N1 virus infection."