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holomycin

structure

Also Known As:

N-(4,5-dihydro-5-oxo-1,2-dithiolo(4,3-b)pyrrol-6- yl)acetamide

Networked: 5 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Amides: 2428
  - Lactams: 2198
    - holomycin: 5
Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Lactams: 2198
    - holomycin: 5

Experts

1.	Gram, Lone: 1 article (11/2021)
2.	Isbrandt, Thomas: 1 article (11/2021)
3.	Larsen, Thomas Ostenfeld: 1 article (11/2021)
4.	Lindqvist, Laura Louise: 1 article (11/2021)
5.	Zhang, Sheng-Da: 1 article (11/2021)
6.	Bie, Xiaomei: 1 article (01/2017)
7.	Lu, Fengxia: 1 article (01/2017)
8.	Lu, Zhaoxin: 1 article (01/2017)
9.	Wang, Juan: 1 article (01/2017)
10.	Wei, Zhaohui: 1 article (01/2017)

Related Diseases

1.	Starvation 11/01/2021 - "Furthermore, zinc starvation was found to be essential for both holomycin production and biofilm formation of S2753, although the molecular mechanism remains elusive. " 01/01/2023 - "Whole-proteome abundance analysis revealed that holomycin treatment induces zinc and iron starvation and cellular stress. "
2.	Atherosclerosis 11/28/2023 - "Accelerated atherosclerosis and neutrophil extracellular trap formation (NETosis) in Tet2 CH mice were reversed by holomycin, a BRCC3 deubiquitinase inhibitor, and also by hematopoietic deficiency of Abro1, an essential scaffolding protein in the BRCC3-containing cytosolic complex. "
3.	Stomach Neoplasms (Stomach Cancer) 01/01/2017 - "Holomycin exhibited cytotoxic activity against A549 lung cancer cells, BGC823 gastric cancer cells and HepG2 hepatocellular carcinoma cells. "
4.	Osteoarthritis 01/01/2023 - "Holomycin, a novel NLRP3 inhibitor, attenuates cartilage degeneration and inflammation in osteoarthritis."
5.	Lung Neoplasms (Lung Cancer) 01/01/2017 - "Holomycin exhibited cytotoxic activity against A549 lung cancer cells, BGC823 gastric cancer cells and HepG2 hepatocellular carcinoma cells. "

Related Drugs and Biologics

1.	Zinc
2.	Proteome
3.	Proteins (Proteins, Gene)
4.	Iron
5.	Deubiquitinating Enzymes