geranyl pyrophosphate

RN given refers to (E)-isomer

Also Known As:

geranyl pyrophosphate, (Z)-isomer; geranyl pyrophosphate, 14C-labeled, (E)-isomer; geranyl pyrophosphate, lithium salt, (E)-isomer; neryl pyrophosphate

Networked: 6 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Terpenes: 1461
    - Polyisoprenyl Phosphates: 3
      - geranyl pyrophosphate: 6
- Organophosphorus Compounds: 300
  - Organophosphates: 1942
    - Polyisoprenyl Phosphates: 3
      - geranyl pyrophosphate: 6

Experts

1.	Gonyeau, Michael J: 1 article (01/2014)
2.	Dandri, Maura: 1 article (09/2012)
3.	Kah, Janine: 1 article (09/2012)
4.	Keller, Amelie Dorothea: 1 article (09/2012)
5.	Montalbano, Roberta: 1 article (09/2012)
6.	Ocker, Matthias: 1 article (09/2012)
7.	Sass, Gabriele: 1 article (09/2012)
8.	Sirma, Hüseyin: 1 article (09/2012)
9.	Tiegs, Gisa: 1 article (09/2012)
10.	Volz, Tassilo: 1 article (09/2012)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2023 - "USP28 depletion rendered cancer cells highly sensitive to MVP inhibition by statins, which was rescued by the addition of geranyl-geranyl pyrophosphate. " 11/24/2008 - "Indeed the cholesterol synthesis pathway plays a pivotal role in dislypidemia and, ultimately, in cancer through intermediates such as mevalonate, farnesyl pyrophosphate and geranyl geranyl pyrophosphate, but no dynamic model of this pathway has been proposed until now. " 01/01/2014 - "Such studies should consider three main end products of the mevalonate pathway (cholesterol, geranyl pyrophosphate, and farnesyl pyrophosphate) from a mechanistic perspective, as well as the potential for cancer cell mediation with statin use, in addition to pertinent clinical end points including cancer incidence and mortality. " 09/01/2012 - "The anti-tumor effect of statins did not depend on a lack of cholesterol production, but was restored by supplementation of mevalonate or geranyl-geranyl pyrophosphate, prerequisites for prenylation of small G proteins. "
2.	Carcinogenesis 01/01/2002 - "Several HMG-CoA metabolites, such as farnesyl pyrophosphate and geranyl pyrophosphate are implicated in oncogene activation and tumorigenesis. "
3.	Wounds and Injuries (Trauma) 02/14/1992 - "The major wound-inducible monoterpene synthase (cyclase) of grand fir (Abies grandis) stems transforms geranyl pyrophosphate to both (-)-alpha-pinene (40%) and (-)-beta-pinene (60%). "

Related Drugs and Biologics

1.	Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)
2.	Mevalonic Acid (Mevalonate)
3.	Cholesterol
4.	farnesyl pyrophosphate (farnesyl diphosphate)
5.	Monomeric GTP-Binding Proteins
6.	pinene cyclase I (limonene synthase)
7.	beta-pinene
8.	3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA)
9.	alpha-pinene