etofenamate

structure

Also Known As:

2-(2-hydroxyethoxy)-ethyl-N-(alpha,alpha,alpha-trifluoro- m-tolyl)anthranilate; Algesalona E; Aspitopic; Bayro; Flogoprofen; Rheuma-Gel-ratiopharm; Rheumon; Traumon; Zenavan; Benzoic acid, 2-((3-(trifluoromethyl)phenyl)amino)-, 2-(2-hydroxyethoxy)ethyl ester

Networked: 59 relevant articles (13 outcomes, 12 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Benzene Derivatives: 17
        Benzoates: 426
        Aminobenzoates: 1
        ortho-Aminobenzoates: 8
        Fenamates: 20
        Flufenamic Acid: 120
        etofenamate: 59
- Carboxylic Acids: 973
  - Carbocyclic Acids
    - Benzoates: 426
      - Aminobenzoates: 1
        ortho-Aminobenzoates: 8
        Fenamates: 20
        Flufenamic Acid: 120
        etofenamate: 59

Experts

1.	Imboden, Roger: 2 articles (08/2021 - 11/2017)
2.	Bulitta, Michael: 1 article (08/2021)
3.	Giannetti, Bruno: 1 article (08/2021)
4.	Leary, Andrew: 1 article (08/2021)
5.	Predel, Hans-Georg: 1 article (08/2021)
6.	Almeida, António J: 1 article (03/2021)
7.	Carvalho, Filomena A: 1 article (03/2021)
8.	Gonçalves, Lídia M D: 1 article (03/2021)
9.	Mancini, Giuliana: 1 article (03/2021)
10.	Marto, Joana: 1 article (03/2021)

Related Diseases

1.	Pain (Aches) 11/17/1983 - "Mobility and circumference of the knee joint as well as pain parameters improved more rapidly in the etofenamate group, whereby the difference between both groups frequently was statistically significant. " 09/01/2023 - "The evaluation of the efficacy of etofenamate spray in postoperative cesarean pain: Randomized, double-blind, placebo-controlled trial." 02/01/2016 - "Molecules like etofenamate have a bioavailability of >20% and evidence for accumulation in synovial tissues, with efficacy demonstrated as improvement in pain and function in real-life studies of OA patients. " 01/01/1977 - "Those patients treated with Rheumon Gel showed improvement in the symptoms spontaneous pain and pain on movement, in a large number of which patients showing improvement, in a large number of which patients showing improvement the spontaneous pain was completely eliminated. " 08/01/2021 - "The responder rate (proportion of patients with at least 50% pain reduction at 72 hours) was 52.5% for the etofenamate plaster and 7.7% for the placebo. "
2.	Ankle Injuries (Ankle Injury) 08/01/2021 - "Randomized controlled trial; Level of evidence, 1. Patients with grade 1 or 2 ankle sprain of recent onset were randomized to etofenamate or placebo plasters (1:1) applied twice daily for 7 days. " 08/01/2021 - "To assess the efficacy and safety of a novel etofenamate 70-mg medicated plaster in patients with acute uncomplicated ankle sprain. " 08/01/2021 - "Efficacy and Safety of an Etofenamate Medicated Plaster for Acute Ankle Sprain: A Randomized Controlled Trial." 08/01/2021 - "With respect to the investigated indication, uncomplicated ankle sprain, the etofenamate plaster has therapeutic efficacy that is similar to that for the best available topical NSAID formulations. " 01/01/1990 - "A double-blind study of the efficacy of topical ketorolac tromethamine gel in the treatment of ankle sprain, in comparison to placebo and etofenamate."
3.	Inflammation (Inflammations) 08/01/1982 - "From these results, it was suggested that etofenamate gel, applied topically to the inflamed tissue, showed a certain inhibitory activity against acute and subacute-chronic inflammation and inflammatory pain-like responses." 03/03/2021 - "Increased Therapeutic Efficacy of SLN Containing Etofenamate and Ibuprofen in Topical Treatment of Inflammation." 12/01/2020 - "These studies demonstrate that topical etofenamate [administered either in gel (5 or 10%), cream (10%) or lotion (10%) formulations)] can improve pain and reduce inflammation in patients with musculoskeletal disorders, including blunt injuries and rheumatic diseases. " 03/03/2021 - "In vivo activity in the rat paw edema inflammation model showed that SLN hydrogels containing lower doses of etofenamate (8.3 times lower) and ibuprofen (16.6 times lower) produced similar effects compared to the commercial formulations, while decreasing edema and inflammatory cell infiltration, and causing no histological changes in the epidermis. "
4.	Erythema 08/01/1982 - "Against acetic acid-induced vascular permeability in mice and ultra-violet light-induced erythema in guinea pigs, etofenamate produced a dose related inhibition at doses of 40--320 mg/kg and 5--20 mg/kg, respectively. " 08/01/1982 - "Etofenamate gel showed a dose related inhibition against vascular permeability caused by histamine in mice and ultra violet light-induced erythema in guinea pigs at doses of 10--100 mg/site and 25--200 (ED50 = 26.6) mg/site, respectively. " 08/01/1982 - "In particular, the anti-erythema, anti-arthritis, and anti-pyretic activities of etofenamate were approximately equivalent to or superior to those of flufenamic acid. " 05/01/1988 - "The results showed that piroxicam in cream formulation, indomethacin cream and etofenamate gel have a similar effect, decreasing the erythema size 7 h after irradiation. " 05/01/1988 - "The aim of this study was to evaluate the inhibitory efficacy of piroxicam in two different topical formulations (cream 0.5, 1 and 1.5% and gel 1%) as compared to three non-steroidal compounds, benzydamine, etofenamate and indomethacin (cream 5%), on erythema induced after UV-injury on the back of 5 healthy subjects. "
5.	Knee Osteoarthritis 01/01/2016 - "The intramuscular application of etofenamate in the treatment of knee osteoarthritis was not observed in the existing English language literature. " 01/01/2016 - "Effectiveness of etofenamate for treatment of knee osteoarthritis: a randomized controlled trial." 01/01/2016 - "The objectives of this study were to compare the efficacy of etofenamate versus hyaluronic acid (HA) in reducing joint pain and functional improvement for mild to moderate knee osteoarthritis. "

Related Drugs and Biologics

1.	Analgesics (Analgesic Drugs)
2.	Non-Steroidal Anti-Inflammatory Agents (NSAIDs)
3.	Indomethacin (Indometacin)
4.	Piroxicam (Feldene)
5.	Lidocaine (Xylocaine)
6.	Hyaluronic Acid (Hyaluronan)
7.	Benzydamine (Tantum)
8.	Diclofenac (SR 38)
9.	Ibuprofen (Motrin)
10.	Ketoprofen (Orudis)

Related Therapies and Procedures

1.	Pain Management
2.	Lithotripsy (Extracorporeal Shockwave Lithotripsy)
3.	Cesarean Section (Caesarean Section)
4.	Therapeutics