|1.||Labeit, Siegfried: 23 articles (05/2015 - 09/2002)|
|2.||Granzier, Henk: 20 articles (02/2015 - 09/2002)|
|3.||Linke, Wolfgang A: 17 articles (11/2015 - 09/2002)|
|4.||Udd, Bjarne: 16 articles (12/2015 - 09/2002)|
|5.||Granzier, Henk L: 11 articles (04/2015 - 07/2003)|
|6.||Vihola, Anna: 10 articles (12/2015 - 09/2002)|
|7.||Hamdani, Nazha: 9 articles (11/2015 - 01/2008)|
|8.||Aarli, J A: 9 articles (06/2007 - 04/2000)|
|9.||Wu, Yiming: 9 articles (02/2007 - 09/2002)|
|10.||Richard, Isabelle: 8 articles (12/2015 - 09/2002)|
|1.||Thymoma (Thymic Carcinoma)
12/01/2003 - "Serum anti-titin antibody test is helpful in the diagnosis of MG with thymoma."
09/01/2010 - "Titin antibody combined with computed tomography was better for the diagnosis of thymoma. "
07/01/2010 - "Serum antititin antibody levels were closely related to titin MIR levels in thymoma cells; however, titin MIR levels did not appear to be related to MG severity. "
07/21/2009 - "The rates of relapse and conversion in OMG with Titin Ab positive or thymomas were higher than OMG with Titin Ab negative or non-thymomas (Log-Rank, P < 0.05). "
12/01/2003 - "According to the Osserman's classification, anti-titin antibody was present mostly in patients (43%) in IV stage, and also present in 2 cases of 7 who with no-MG thymoma. "
02/01/2015 - "Four weeks of volume overload resulted in significant biventricular hypertrophy; protein expression analysis in left ventricular (LV) tissue showed a marked decrease in titin's N2BA/N2B ratio with no change in phosphorylation of titin's spring region. "
12/01/2008 - "Mechanistic studies demonstrated that FHL1 plays an important role in the mechanism of pathological hypertrophy by sensing biomechanical stress responses via the N2B stretch sensor domain of titin and initiating changes in the titin- and MAPK-mediated responses important for sarcomere extensibility and intracellular signaling. "
11/01/2015 - "In LV biopsies, we observed myocyte hypertrophy, a shift toward the stiffer titin isoform N2B, and reduced total titin phosphorylation. "
01/01/2015 - "Pressure Overload by Transverse Aortic Constriction Induces Maladaptive Hypertrophy in a Titin-Truncated Mouse Model."
07/01/2010 - "Changes in the expression of N2B- and N2BA-isoforms of titin in the left ventricle of the myocardium of spontaneously hypertensive rats during the development of hypertrophy have been analyzed by the methods of real-time scale polymerase chain reaction and SDS gel electrophoresis. "
01/01/2013 - "No changes in the phosphorylation level of the PEVK element were found suggesting that the increased phosphorylation level of titin in IR (ischemia reperfusion) might be due to phosphorylation of the N2B element. "
11/16/2010 - "Titin degradation was also reduced in hearts from MMP-2 knockout mice subjected to ischemia/reperfusion in vivo compared with wild-type controls. "
11/16/2010 - "Here we determine whether titin is an intracellular substrate for MMP-2 and if its degradation during ischemia/reperfusion contributes to cardiac contractile dysfunction. "
11/16/2010 - "Inhibition of MMP activity with ONO-4817 prevented ischemia/reperfusion-induced titin degradation and improved the recovery of myocardial contractile function. "
02/27/2004 - "alphaB-crystallin in cardiac muscle binds to myofibrils under conditions of ischemia, and previous work has shown that the protein binds to titin in the I-band of cardiac fibers (Golenhofen, N., Arbeiter, A., Koob, R., and Drenckhahn, D. "
06/01/1996 - "However, the stimulus for these responses remains enigmatic as whole titin is not detectable in these tumors. "
06/01/1996 - "Expression of neurofilaments and of a titin epitope in thymic epithelial tumors. "
01/01/1996 - "However, the stimulus for this autoimmunity remains enigmatic since whole titin is not detectable in these tumors. "
09/01/2008 - "Tumor cells were positive for vimentin and titin. "
11/13/2001 - "As previously reported, titin antibodies were uncommon in patients with early-onset MG. However, in patients with late-onset MG, titin antibodies had similar prevalence and levels to those in patients with MG and thymoma, although the antibodies were uncommon in patients between 40 and 60 years of age presenting without a tumor. "
|5.||Body Weight (Weight, Body)
04/01/2007 - "Results revealed a significant reduction in body weight of the T45 mice and a significant increase in titin expression (% titin immunoreactivity median [range] = 41.11 [20-60] vs. 30.00 [10-50]). "
07/01/2003 - "Regression analysis of titin isoform ratios, myosin heavy chain isoform ratios, and heart weight to body weight ratios all suggest a smaller proportion of N2BA titin (longer isoform) was expressed in rat left ventricles with increased hypertrophy. "
|2.||Interleukin-12 (IL 12)
|6.||myosin-binding protein C
|8.||Proteins (Proteins, Gene)
|2.||Protein-Restricted Diet (Diet, Protein Restricted)