|1.||O'Brien, Peter J: 1 article (05/2008)|
|2.||Mashregi, Mariam: 1 article (05/2008)|
|3.||Tafazoli, Shahrzad: 1 article (05/2008)|
|4.||De Rosa, Helene J: 1 article (09/2007)|
|5.||Brunetti, Iguatemy L: 1 article (09/2007)|
|6.||Ximenes, Valdecir F: 1 article (09/2007)|
|7.||Machado, Rosângela G P: 1 article (09/2007)|
|8.||Baldan, Helen M: 1 article (09/2007)|
|2.||Body Weight (Weight, Body)
09/01/2007 - "Since these hepatotoxic events have been associated with INH metabolites, the study aimed to measure the area under curve (AUC) parameter for INH and its metabolites acetylisoniazid (AcINH), hydrazine (Hz) and acetylhydrazine (AcHz), when groups of rats were pre-treated for 21 days with INH alone or in combination with RMP and/or PYR, in the following amounts per kg body weight: INH 100 mg; INH 100 mg + RMP 100 mg; INH 100 mg + PYR 350 mg; INH 100 mg + PYR 350 mg + RMP 100 mg. It was found that co-administration of RMP, PYR and RMP + PYR caused a significant decrease in the AUC for INH. "
01/01/1996 - "Plasma INH and acetylhydrazine were not correlated with markers of INH-induced hepatic necrosis or fatty changes. "
04/01/1994 - "The effect of vitamin B6 deficiency on acetylhydrazine hepatic necrosis."
01/01/1996 - "These results show in this model of INH-induced hepatotoxicity in rabbits that hydrazine, and not INH or acetylhydrazine, is most likely involved in the pathogenic mechanism of hepatic necrosis."
05/01/1980 - "These results strongly suggest that acetylhydrazine is the metabolite responsible for the hepatic necrosis caused by isoniazid and that mirosomal metabolism of acetylhydrazine in vivo leads to the production of a reactive acylating species capable of reacting covalently with tissue macromolecules."
01/01/1996 - "Using a model of INH-induced hepatotoxicity in rabbits, in which INH-induced hepatotoxicity manifests as hepatic necrosis, hepatic steatosis (hepatic fat accumulation) and hypertriglyceridaemia (elevated plasma triglycerides), we compared the severity of these measures of toxicity with plasma levels of INH, acetylhydrazine and hydrazine. "
05/15/2008 - "The acetylhydrazine metabolite was found to be much less cytotoxic than hydrazine in this hepatocyte inflammation model. "
01/01/1989 - "The results of the experiments with use of isoniazid and its metabolites showed that in the liver of rats isoniazid induced albuminous degeneration with stroma inflammation and hepatocyte necrosis, monoacetylhydrazine induced fatty hepatosis, acetylisoniazid induced fatty hepatosis with stroma inflammation and hepatocyte necrosis and isonicotinic acid induced granular degeneration. "
|5.||Vitamin B 6 Deficiency (Pyridoxine Deficiency)
|1.||hydrazine (hydrazine dihydrochloride)
|5.||Isonicotinic Acids (Isonicotinic Acid)