RMI 12330A

adenyl cyclase inhibitor in rat liver; RN given refers to (cis)-isomer; NM refers to HCl, (cis)-isomer; structure

Also Known As:

MDL 12330A; MDL-12,330A; MDL-12330A; MDL12330A; N-(cis-2-phenylcyclopentyl)azacyclotridecan-2-imine.HCl; RMI 12330 A; RMI 12330A, hydrochloride, (cis)-isomer; azacyclotridec-1-en-2-amine, N-(2-phenylcyclopentyl)-, cis-

Networked: 8 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Imines: 310
  - RMI 12330A: 8

Experts

1.	Lakhter, Alexander J: 1 article (10/2017)
2.	Naidu, Samisubbu R: 1 article (10/2017)
3.	Han, Song Iy: 1 article (07/2017)
4.	Lim, Sung-Chul: 1 article (07/2017)
5.	Cui, Meiyu: 1 article (01/2012)
6.	Kong, Xianglei: 1 article (01/2012)
7.	Li, Wenbin: 1 article (01/2012)
8.	Tang, Lijun: 1 article (01/2012)
9.	Wei, Yong: 1 article (01/2012)
10.	Xu, Dongmei: 1 article (01/2012)

Related Diseases

1.	Stomach Neoplasms (Stomach Cancer) 07/01/2017 - "This study demonstrates a possible role of MDL-12330A as a potential sensitizer to TRAIL, and suggests a novel therapeutic strategy targeting gastric cancer cells." 07/01/2017 - "MDL-12330A potentiates TRAIL-induced apoptosis in gastric cancer cells through CHOP-mediated DR5 upregulation." 07/01/2017 - "More importantly, low concentrations of MDL-12330A effectively enhanced recombinant human tumor necrosis factor (TNF)-related apoptosis-inducing ligand (rhTRAIL)-induced apoptosis and clonogenicity in these gastric cancer cells. "
2.	Hypoxia (Hypoxemia) 01/01/2005 - "Hypoxia-induced neurite outgrowth was blocked by the adenylate cyclase inhibitor, MDL-12,330A, indicating a role for activation of this enzyme in the pathway. " 07/01/1991 - "Inhibition of the adenylate cyclase by N-(cis-2-phenylcyclopentyl)azacyclotridecan-2-imine hydrochloride (MDL 12330A; 20-1,000 microM) under zero-Ca2+ conditions irreversibly inhibited the cyclic AMP increase produced by hypoxia. "
3.	Ganglion Cysts (Ganglion) 12/12/1983 - "An adenylate cyclase inhibitor, RMI 12330A, is able to depress cAMP synthesis stimulated by serotonin in the abdominal ganglion of Aplysia depilans and punctata. "
4.	Stroke (Strokes) 11/01/1980 - "2 In the isolated work-performing heart of the guinea-pig, RMI 12330A (IC50 of 1.1 X 10(-6) M) depressed all cardiac functions: pressures developed, dP/dt, contractile force, dF/dt, work performance and stroke work. "
5.	Neoplasms (Cancer) 09/01/2003 - "Exposure of NK cells to the AC inhibitors MDL-12,330A (MDL) or 2',5',-Dideoxyadenosine (DDA) completely blocked their ability to destroy K562 tumor cells. "

Related Drugs and Biologics

1.	Adenylyl Cyclases (Adenylyl Cyclase)
2.	TNF-Related Apoptosis-Inducing Ligand
3.	Cyclic AMP-Dependent Protein Kinases (cAMP-Dependent Protein Kinase)
4.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
5.	Serotonin (5 Hydroxytryptamine)
6.	Enzymes
7.	Cyclic AMP (AMP, Cyclic)
8.	bis(p-chlorophenyl)acetic acid (DDA)