IPS 339

RN refers to mono-HCl without isomeric designation; structure

Also Known As:

(t-butyl-3-amino-2-propanol)-9-oximinofluorene.HCl; IPS 339, monohydrochloride, (+-)-isomer; IPS-339; 9H-fluoren-9-one, O-(3-((1,1-dimethylethyl)amino)-2-hydroxypropyl)oxime, monohydrochloride

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Amines: 4871
  - Amino Alcohols: 20
    - Propanolamines: 4
      - IPS 339: 2
- Alcohols: 595
  - Amino Alcohols: 20
    - Propanolamines: 4
      - IPS 339: 2
  - Propanols: 3
    - Propanolamines: 4
      - IPS 339: 2

Related Diseases

1.	Tachycardia (Tachyarrhythmias) 02/01/1981 - "Ratios of doses causing a 50% inhibition of tachycardia to that on hypotension induced by isoprenaline were as follows: D-32 (0.69), propranolol (0.67), atenolol (0.03) and IPS-339 (6.3). "
2.	Anorexia 01/20/1986 - "Neither IPS 339 nor metoprolol injected in the perifornical hypothalamus significantly modified the anorectic effect of diethylpropion (5 mg/kg i.p.) whereas it was partially prevented by intraperifornical injection of 1-propranolol (52 micrograms/2 microliter), a non-selective beta antagonist, suggesting that both beta 1 and beta 2 adrenergic receptors in the hypothalamus contribute to the mechanism by which diethylpropion causes anorexia."

Related Drugs and Biologics

1.	beta-2 Adrenergic Receptors
2.	Propranolol (Inderal)
3.	Metoprolol (Toprol-XL)
4.	Isoproterenol (Isoprenaline)
5.	Diethylpropion (Amfepramone)
6.	Atenolol (Tenormin)
7.	Appetite Depressants (Anorectics)

Related Therapies and Procedures

1.	Controlled Hypotension