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FLA 136

RN given refers to parent cpd
Also Known As:
4-amino-3-(2,6-dichlorobenzylidenehydrazino)-1,2,4-triazole; FLA 136, monohydrochloride; FLA-136; 2,6-dichlorobenzaldehyde, (4-amino-4H-1,2,4-triazol-3-yl)hydrazone
Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Related Diseases

1. Hypotension (Low Blood Pressure)
01/01/1982 - "The effects of both drugs on pre- and postsynaptic alpha-adrenoceptors in the periphery have been investigated after intravenous (i.v.) administration in the pithed rat.2 In the anaesthetized rat, i.c.v. FLA-136 and clonidine produced dose-related hypotension, FLA-136 having three to 30 times less activity than clonidine; both drugs caused concomitant bradycardia. "
01/01/1982 - "In the conscious rat i.c.v. FLA-136 had less sedative potential than clonidine, in terms of overt sedation assessed visually.3 Yohimbine reduced the hypotension and bradycardia produced by i.c.v. FLA-136 and clonidine; prazosin and mianserin also antagonized the cardiovascular responses to clonidine, but not those to FLA-136.4 Chemical sympathectomy by 6-hydroxydopamine (6-OHDA) markedly reduced the cardiovascular effects of FLA-136 but only slightly reduced those of clonidine.5 Naloxone antagonized the cardiovascular responses to clonidine, but not FLA-136, suggesting a direct or indirect involvement of central opiate receptors in the responses induced by clonidine.6 Metiamide attenuated the cardiovascular responses to FLA-136 and clonidine, implying a direct or indirect involvement of central histamine (H(2))-receptors in such responses.7 FLA-136, unlike clonidine, did not stimulate peripheral pre- or postsynaptic alpha-adrenoceptors in the pithed rat.8 FLA-136 is a novel centrally-acting hypotensive compound which, unlike clonidine, selectively stimulates central alpha-autoreceptors (yohimbine-sensitive) in the rat; these autoreceptors may be different from peripheral pre- and postsynaptic alpha-adrenoceptors. "
2. Bradycardia
01/01/1982 - "The effects of both drugs on pre- and postsynaptic alpha-adrenoceptors in the periphery have been investigated after intravenous (i.v.) administration in the pithed rat.2 In the anaesthetized rat, i.c.v. FLA-136 and clonidine produced dose-related hypotension, FLA-136 having three to 30 times less activity than clonidine; both drugs caused concomitant bradycardia. "
01/01/1982 - "In the conscious rat i.c.v. FLA-136 had less sedative potential than clonidine, in terms of overt sedation assessed visually.3 Yohimbine reduced the hypotension and bradycardia produced by i.c.v. FLA-136 and clonidine; prazosin and mianserin also antagonized the cardiovascular responses to clonidine, but not those to FLA-136.4 Chemical sympathectomy by 6-hydroxydopamine (6-OHDA) markedly reduced the cardiovascular effects of FLA-136 but only slightly reduced those of clonidine.5 Naloxone antagonized the cardiovascular responses to clonidine, but not FLA-136, suggesting a direct or indirect involvement of central opiate receptors in the responses induced by clonidine.6 Metiamide attenuated the cardiovascular responses to FLA-136 and clonidine, implying a direct or indirect involvement of central histamine (H(2))-receptors in such responses.7 FLA-136, unlike clonidine, did not stimulate peripheral pre- or postsynaptic alpha-adrenoceptors in the pithed rat.8 FLA-136 is a novel centrally-acting hypotensive compound which, unlike clonidine, selectively stimulates central alpha-autoreceptors (yohimbine-sensitive) in the rat; these autoreceptors may be different from peripheral pre- and postsynaptic alpha-adrenoceptors. "

Related Drugs and Biologics

1. Autoreceptors
2. Oxidopamine (6 Hydroxydopamine)
3. Yohimbine (Yocon)
4. Opioid Receptors (Opioid Receptor)
5. Adrenergic Receptors (Adrenergic Receptor)
6. Prazosin (Minipress)
7. Naloxone (Narcan)
8. Mianserin
9. Metiamide
10. Histamine (Histamine Dihydrochloride)

Related Therapies and Procedures

1. Chemical Sympathectomy