|1.||Zhou, Shu-Feng: 7 articles (01/2015 - 01/2013)|
|2.||He, Zhi-Xu: 6 articles (01/2015 - 03/2014)|
|3.||Zhou, Zhi-Wei: 6 articles (01/2015 - 03/2014)|
|4.||Zhang, Xueji: 6 articles (01/2015 - 03/2014)|
|5.||Qiu, Jia-Xuan: 6 articles (01/2015 - 03/2014)|
|6.||Sandur, Santosh K: 5 articles (02/2015 - 06/2006)|
|7.||Wang, Dong: 5 articles (01/2015 - 08/2014)|
|8.||Ahmad, Aamir: 5 articles (07/2014 - 12/2008)|
|9.||Srinivas, Priya: 5 articles (05/2013 - 01/2004)|
|10.||Yan, Wei: 4 articles (09/2015 - 12/2013)|
11/01/2014 - "However, the therapeutic efficacy of plumbagin is overshadowed by the lack of sensitivity and selectivity towards cancer cells. "
02/01/2015 - "The in vivo anti-tumor efficacy of plumbagin was demonstrated using a mouse model. "
10/01/2015 - "To study the effects of plumbagin (PLB), a relatively non-toxic napthaquinone isolated from the roots of Plumbago indica in human cervical cancer cell line and developed a formulation to enhance its cytotoxic activities. "
01/01/2014 - "In the present study, plumbagin and its five derivatives have been evaluated for their antiproliferative potential in one normal and four human cancer cell lines. "
09/01/2009 - "The objective of the present study was to determine whether plumbagin induces apoptosis in human cancer cells through the same mechanism which we proposed earlier. "
|2.||Breast Neoplasms (Breast Cancer)
09/01/2015 - "The aim of this study was to investigate the effects of ZA combined with a natural anticancer compound plumbagin (PL) against human breast cancer cells in vitro. "
12/01/2013 - "The aim of this study was to investigate the effects of plumbagin (PL), a naphthoquinone derived from the medicinal plant plumbago zeylanica, on the invasion and migration of human breast cancer cells. "
12/01/2006 - "This study is the first to investigate the anticancer effect of plumbagin in human breast cancer cells. "
12/01/2013 - "Plumbagin can suppress the invasion and migration of breast cancer cells via the inhibition of STAT3 signaling and by downregulation of IL-1α, TGF-β, MMP-2 and MMP-9."
12/01/2013 - "Non-invasive in vivo monitoring, X-ray imaging and histological staining were performed to investigate the effects of plumbagin on the invasion and migration of breast cancer cells in vivo. "
01/01/2013 - "This study aimed to investigate the inhibitory effect and the underlying mechanism of plumbagin on the growth of human tongue carcinoma cells. "
01/01/2013 - "Plumbagin induces the apoptosis of human tongue carcinoma cells through the mitochondria-mediated pathway."
01/01/2009 - "We investigated the effect of plumbagin on the growth of human pancreatic carcinoma cells and its possible underlying mechanisms. "
07/29/2008 - "Cell viability experiments using human non-small lung epithelium carcinoma cells (A549) indicated that the IC 50 value for plumbagin is 14.6 microM. "
04/01/1997 - "Reduced toxicity and enhanced antitumor efficacy of betacyclodextrin plumbagin inclusion complex in mice bearing Ehrlich ascites carcinoma."
|4.||Colonic Neoplasms (Colon Cancer)
11/01/2014 - "In light of its previously reported lack of toxicity on normal colon cells and the striking anti-survival effect on colon cancer cells observed in our study, Plumbagin should be considered a promising drug for the treatment of colon cancer. "
01/01/2011 - "In this study we investigated the anti-proliferative and apoptotic activity of plumbagin by using two human colonic cancer cell lines, HT29 and HCT15. "
11/01/2014 - "Plumbagin reduces human colon cancer cell survival by inducing cell cycle arrest and mitochondria-mediated apoptosis."
10/01/2013 - "Further, after plumbagin treatment, activated AMPK directly phosphorylates Raptor to inhibit mTOR complex 1 (mTORC1) activation and Bcl-2 expression in colon cancer cells. "
01/01/2011 - "In conclusion, plumbagin induces apoptosis in colonic cancer cells through TNF-α mediated pathway depending on expression of COX-2 expression."
|5.||Pancreatic Neoplasms (Pancreatic Cancer)
01/01/2009 - "It indicates that plumbagin can be potentially developed as a novel therapeutic agent against pancreatic cancer."
01/01/2015 - "Plumbagin (PLB), an active naphthoquinone compound, has shown potent anticancer effects in preclinical studies; however, the effect and underlying mechanism of PLB for the treatment of pancreatic cancer is unclear. "
01/01/2015 - "Plumbagin induces cell cycle arrest and autophagy and suppresses epithelial to mesenchymal transition involving PI3K/Akt/mTOR-mediated pathway in human pancreatic cancer cells."
11/01/2012 - "Plumbagin, a plant derived natural agent inhibits the growth of pancreatic cancer cells in in vitro and in vivo via targeting EGFR, Stat3 and NF-κB signaling pathways."
01/01/2009 - "Plumbagin may induce apoptosis in human pancreatic cancer cells primarily through the mitochondria-related pathway followed by both caspase-dependent and caspase-independent cascades. "
|4.||Epidermal Growth Factor Receptor (EGF Receptor)
|6.||Urokinase-Type Plasminogen Activator (Urokinase)
|7.||Janus Kinase 2
|1.||Heterologous Transplantation (Xenotransplantation)
|2.||Traditional Medicine (Folk Remedies)