piperazic acid

inhibitor of GABA; cpd not in Chemline 8/18/83; structure

Also Known As:

hexahydropyridazine-3-carboxylic acid; piperazic acid, (R)-isomer; piperazic acid, (S)-isomer

Networked: 2 relevant articles (1 outcomes, 0 trials/studies)

1.	Seizures (Absence Seizure) 10/26/1979 - "Protection against audiogenic seizures was seen 30 min after the icv injection of (+)-2,4-diaminobutyric acid (0.5-2.0 mumoles), (+/-)-nipecotic acid (1.6-3.2 mumoles), (+)-ethyl nipecotate (0.4-0.8 mumoles), (-)-piperazic acid (4 mumoles) and putrescine (2 mumoles) or the ip injection of (+)-2,4-diaminobutyric acid (4-8 mmoles/kg and (+)-ethyl nipecotate (0.24-0.32 mmoles/kg). "
2.	Infections 01/01/2019 - "Discovery of piperazic acid peptide deformylase inhibitors with in vivo activity for respiratory tract and skin infections."