mercaptoundecahydrododecaborate (borocaptate sodium)

agent used for the boron-neutron capture therapy of brain tumor; incorporated selectively into malignant tissue; RN given refers to parent cpd; structure

Also Known As:

borocaptate sodium; mercaptoundecahydrododecaborate, 10B-labeled; mercaptoundecahydrododecaborate, dicesium salt; mercaptoundecahydrododecaborate, dicesium salt, 10B-labeled; mercaptoundecahydrododecaborate, dicesium salt, 12SH; mercaptoundecahydrododecaborate, dicesium salt, labeled with tritium; mercaptoundecahydrododecaborate, disodium salt; mercaptoundecahydrododecaborate, sodium salt; sodium borocaptate (Na2B12H11SH); sodium borocaptate-10B; sodium undecahydromercapto-closo-dodecaborate; sulfhydryl borane monomer; sulfhydryl boron hydride

Networked: 49 relevant articles (0 outcomes, 11 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Suzuki, Minoru: 7 articles (01/2021 - 03/2004)
2.	Ono, Koji: 7 articles (12/2019 - 12/2002)
3.	Sakurai, Yoshinori: 7 articles (12/2019 - 12/2002)
4.	Kinashi, Yuko: 5 articles (11/2009 - 12/2002)
5.	Nagata, Kenji: 5 articles (11/2009 - 03/2004)
6.	Maruhashi, Akira: 4 articles (12/2019 - 11/2004)
7.	Masunaga, Shin-Ichiro: 3 articles (12/2019 - 05/2004)
8.	Tanaka, Hiroki: 2 articles (12/2019 - 11/2009)
9.	Masunaga, Shin-ichiro: 2 articles (11/2009 - 12/2002)
10.	Masunaga, Shinichiro: 2 articles (11/2004 - 03/2004)

Related Diseases

1.	Neoplasms (Cancer) 03/04/2022 - "Compared with clinical drug Borocaptate Sodium (BSH), DOX-CB@lipo-pDNA-iRGD significantly enhances the survival rate of tumor-bearing mice, reduces tumor stemness, and improves the prognosis. " 12/01/2002 - "After administration of sodium borocaptate-10B (BSH) or p-boronophenylalanine-10B (BPA), the tumors were irradiated with neutron beams. " 10/01/2000 - "After borocaptate sodium (BSH) and boronophenylalanine (BPA) administration, (10)B concentrations were measured in tumors and liver and the liver was irradiated with thermal neutrons. " 04/30/1993 - "With respect to these findings borocaptate sodium can by no means be regarded as an agent which is fully devoid of activity towards healthy non-tumor tissue. " 11/01/2001 - "injection of sodium borocaptate-10B (BSH), or 3 h after oral administration of p-boronophenylalanine-10B (BPA), the tumors were irradiated with neutron beams. "
2.	Melanoma (Melanoma, Malignant) 11/01/1985 - "[Kinetics of the cell population of transplantable murine B-16 melanoma after administration of mercaptoundecahydrododecaborate enriched with 10B]." 02/01/2000 - "The aim of this study was to test whether electroporation can be used as a non-specific drug delivery system to increase the delivery of sodium borocaptate-10B (BSH) into MCF7 (breast carcinoma) and B16F1 (melanoma) tumour cells in vitro and in B16F1 tumours in vivo. " 07/01/2000 - "Uptake and washout of borocaptate sodium and borono-phenylalanine in cultured melanoma cells: a multi-nuclear NMR study." 06/01/1998 - "The survival of human melanoma cells has been determined by a colony assay and the sulforhodamine-B assay after X-irradiation and irradiation with fast d(14) + Be-neutrons using the boronated compound borocaptate sodium (BSH). " 01/01/1989 - "Distributions of sulfhydryl borane monomer and dimer in rodents and monomer in humans: boron neutron capture therapy of melanoma and glioma in boronated rodents."
3.	Brain Neoplasms (Brain Tumor) 10/01/1997 - "Kidney function changes after single-dose administration of borocaptate sodium were studied in rats and in patients with brain tumors. " 07/01/1995 - "A 3D projection reconstruction (3DPR) method was used to obtain in vivo 11B images in a large canine brain tumor model and in a human infused with borocaptate sodium (BSH). " 02/01/1997 - "Sodium borocaptate (Na2B12H11SH or BSH) has been used clinically for boron neutron capture therapy (BNCT) of patients with primary brain tumors. " 06/01/1998 - "Disposition and tissue distribution of boron after infusion of borocaptate sodium in patients with malignant brain tumors." 10/01/1997 - "The diuretic effect of borocaptate sodium in rats and in patients with brain tumors."
4.	Glioma (Gliomas) 03/15/1992 - "Sulfhydryl boron hydride (BSH) (10B enriched) is presently used for boron neutron capture therapy of malignant gliomas. " 03/15/1992 - "Accumulation of 10B in the central degenerative areas of human glioma and colon carcinoma spheroids after sulfhydryl boron hydride administration." 07/01/1995 - "This study is undertaken in the present work, in which the biodistribution and pharmacokinetics of sulfhydryl boron hydride (BSH) and boronated porphyrin (BOPP) in the RG2 rat glioma model are investigated. " 07/01/1995 - "A comparative study on the pharmacokinetics and biodistribution of boronated porphyrin (BOPP) and sulfhydryl boron hydride (BSH) in the RG2 rat glioma model." 01/01/1989 - "Distributions of sulfhydryl borane monomer and dimer in rodents and monomer in humans: boron neutron capture therapy of melanoma and glioma in boronated rodents."
5.	Glioblastoma (Glioblastoma Multiforme) 10/15/1987 - "In a transplantable Harding-Passey melanoma in mice, it was found that the sulfhydryl boron hydride Na2B12H11SH presently used for therapy of glioblastoma clears blood, muscle, and brain very rapidly. " 06/01/1998 - "The kinetics of boron disposition after an infusion of borocaptate sodium (25 mg/kg body wt over the period of 1 h) was studied in a group of 10 patients with astrocytoma or glioblastoma of cerebral hemispheres using a modification of the Soloway-Messer colorimetric method. " 04/01/1993 - "Borocaptate sodium (BSH) and L-boronophenylalanine (L-BPA) are two boron carriers used for boron neutron capture therapy (BNCT) in the treatment of glioblastoma and melanoma, respectively. " 07/01/1998 - "The two porphyrins with the greatest potential for application to boron neutron capture therapy (BNCT), NiTCP and NiTCP-H, yielded higher tumour:blood and tumour:brain boron concentration ratios in mice than could be achieved with p-boronophenylalanine (BPA) and sodium mercaptoundecahydrododecaborate (BSH), the compounds which are currently being used in clinical trials of BNCT in the treatment of glioblastoma. "

Related Drugs and Biologics

1.	Boron
2.	Porphyrins
3.	Phenylalanine (L-Phenylalanine)
4.	4-boronophenylalanine
5.	Sodium
6.	Ethiodized Oil (Ethiodol)
7.	Emulsions
8.	Transferrin (beta 2 Transferrin)
9.	Phosphatidylcholines (Phosphatidylcholine)
10.	Liposomes (Liposome)

Related Therapies and Procedures

1.	Boron Neutron Capture Therapy
2.	Radiotherapy
3.	Therapeutics
4.	Intraperitoneal Injections
5.	Injections