|1.||Kumagai, Takeshi: 2 articles (08/2015 - 11/2008)|
|2.||Gollapudi, B Bhaskar: 2 articles (09/2012 - 11/2008)|
|3.||Jeong, Yo-Chan: 2 articles (09/2012 - 11/2008)|
|4.||Zhang, Fagen: 2 articles (09/2012 - 11/2008)|
|5.||Geter, David R: 2 articles (09/2012 - 11/2008)|
|6.||Wood, Amanda J: 2 articles (09/2012 - 11/2008)|
|7.||Schisler, Melissa R: 2 articles (09/2012 - 11/2008)|
|8.||Bartels, Michael J: 2 articles (09/2012 - 11/2008)|
|9.||Okazaki, Maiko: 2 articles (07/2011 - 11/2008)|
|10.||Yamamoto, Masako: 2 articles (07/2011 - 11/2008)|
08/05/2014 - "Diethyl maleate inhibits MCA+TPA transformed cell growth via modulation of GSH, MAPK, and cancer pathways."
08/01/2000 - "The uptake of [(99m)Tc]-d,l-HMPAO in tumor was significantly decreased by the diethyl maleate (DEM) treatment. "
10/01/1983 - "Potentiating effect of diethyl maleate (DEM) on the radiosensitization of MISO was also studied using the same experimental tumor. "
09/01/1988 - "Another experiment demonstrated that when papillomas received repeated topical applications of diethylmaleate, a GSH-depleting agent, tumor progression was enhanced. "
10/01/1986 - "Large radiosensitization of C3H/He mouse mammary tumors was obtained with the combination of a non-protein sulfhydryl (NPSH) depletor, diethyl maleate (DEM), and misonidazole (MISO), compared with MISO alone over a range of MISO dose. "
05/01/2000 - "The aim of this study was to determine the effects of a thiol-depleting agent, diethylmaleate (DEM), on androgen sensitive and insensitive prostate carcinoma cells. "
08/01/2015 - "We have previously reported that electrophiles including diethyl maleate (DEM), heavy metals and cigarette smoke extracts induced ASMase expression in human bladder carcinoma ECV-304 cells, but the mechanism of ASMase mRNA induction by electrophiles remains unknown. "
09/01/1981 - "The role of glutathione in the biological effects of cyclophosphamide (CP) was evaluated by investigating the following: effect of CP on hepatic glutathione levels; relationship between hepatic glutathione depletion (repletion) and the binding of [chloroethyl-3H]CP and [4-14C]CP to hepatic macromolecules; effects of interaction between CP (or acrolein) and diethyl maleate (a classical glutathione depletor), and/or between CP and cysteine on the binding of labeled CP to hepatic macromolecules, on the induction of hematuria, on the content of hepatic cytochrome P-450, on weight gain in rats, on survival in mice, and on the chemotherapeutic efficacy of CP against Walker 256 carcinoma in rats. "
|3.||Acute Liver Failure (Fulminant Hepatic Failure)
01/01/2015 - "In the current study, we demonstrated the pivotal role of antioxidant levels in human umbilical cord mesenchymal stem cells (hUCMSCs) dynamic in vitro anti-stress abilities against lipopolysaccharide (LPS)/H2O2 intoxication and in vivo therapeutic efficacy in a murine acute liver failure model induced by D-galactosamine/LPS (Gal/LPS) by either reducing the antioxidant levels with diethyl maleate (DEM) or increasing antioxidant levels with edaravone. "
09/01/1999 - "Redox manipulation using the thiol-oxidizing agent diethyl maleate prevents hepatocellular necrosis and apoptosis in a rodent endotoxemia model."
11/01/1990 - "Pretreatment of mice with diethyl maleate increased the incidence and severity of hepatic necrosis, whereas that with either cysteine or CoCl2 reduced the severity of centrilobular necrosis of the liver. "
07/01/1985 - "Depletion of protective intracellular GSH by diethyl maleate treatment (400 mg/kg) alone minimally decreased control plasma membrane uptake activity, although the GSH depletion markedly potentiated the effect of acetaminophen on the plasma membrane and on necrosis. "
11/01/1983 - "The administration of 500 mumol of styrene oxide to perfused livers from diethyl maleate-treated rats caused periportal necrosis and extensive covalent binding of styrene oxide-derived radioactivity to tissue protein. "
02/01/2004 - "Oxidative stress appears to be central in usnic acid-induced hepatotoxicity based on the following findings: (1) pretreatment with antioxidants (butylated hydroxytoluene+Vitamin E) decreased usnic acid-induced necrosis by nearly 70%; (2) depletion of mitochondrial GSH with diethylmaleate increased susceptibility of hepatocytes to usnic acid; (3) usnic acid treatment was associated with increase free radical generation, measured using the fluorescent probe, dichlorodihydrofluorescin. "
07/01/2011 - "Thus, we investigated whether VKs also have protective effects against GSH-depletion-induced cell death by employing two GSH reducers, L-buthionine sulfoximine (BSO) and diethyl maleate (DEM), in primary cultured neurons and human neuroblastoma IMR-32 cells. "
11/15/2008 - "Therefore, to understand the mechanism by which DPQ inhibits cytotoxicity, we first studied the effect of DPQ on buthionine sulfoximine- or diethyl maleate-induced death of primary cultured cells and human neuroblastoma IMR-32 cells, both of which are mediated by GSH depletion. "
|1.||Glutathione (Reduced Glutathione)
|7.||Cytochrome P-450 Enzyme System (Cytochrome P450)