deoxypodophyllotoxin

RN given refers to cpd without isomeric designation; structure in second source

Also Known As:

deoxypicropodophyllin; deoxypodophyllotoxin, (5R-(5alpha,5aalpha,8aalpha))-isomer; deoxypodophyllotoxin, (5R-(5alpha,5aalpha,8abeta))-isomer; deoxypodophyllotoxin, (5R-(5alpha,5abeta,8aalpha))-isomer; deoxypodophyllotoxin, (5R-(5alpha,5abeta,8abeta))-isomer; deoxypodophyllotoxin, (5alpha,5aalpha,8aalpha)-(+-)-isomer; deoxypodophyllotoxin, (5alpha,5aalpha,8abeta)-(+-)-isomer; isoanthricin; isodeoxypodophyllotoxin; 5,8,8a,9-tetrahydro-5-(3,4,5-trimethoxyphenyl)furo(3',4':6,7)naphtho(2,3-d)-1,3-dioxol-6(5aH)-one

Networked: 40 relevant articles (1 outcomes, 4 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Zhu, Xiong: 6 articles (01/2018 - 10/2013)
2.	Shim, Jung-Hyun: 3 articles (04/2021 - 05/2019)
3.	Yoon, Goo: 3 articles (04/2021 - 05/2019)
4.	Ahn, Soon-Cheol: 3 articles (10/2018 - 05/2013)
5.	Kim, Kwang-Youn: 3 articles (10/2018 - 05/2013)
6.	Kim, Sang-Hun: 3 articles (10/2018 - 05/2013)
7.	Yu, Sun-Nyoung: 3 articles (10/2018 - 05/2013)
8.	Jiang, Zhen-Zhou: 3 articles (10/2016 - 01/2015)
9.	Zhang, Lu-Yong: 3 articles (10/2016 - 01/2015)
10.	Guerram, Mounia: 3 articles (10/2015 - 01/2015)

Related Diseases

1.	Hypersensitivity (Allergy) 05/01/2004 - "These results suggest that deoxypodophyllotoxin may be beneficial in regulating the immediate-type allergic reaction."
2.	Neoplasms (Cancer) 01/20/2015 - "Deoxypodophyllotoxin (DPT), a natural microtubule destabilizer, was isolated from Anthriscus sylvestris, and a few studies have reported its anti-cancer effect. " 08/05/2022 - "This review comprehensively describes the influence of deoxypodophyllotoxin on signaling cascades and molecular targets implicated in cancer cell proliferation and invasion. " 01/01/2021 - "The anti-tumor activity of deoxypodophyllotoxin derivatives was investigated by the MTT assay method. " 01/01/2021 - "In this article, a series of deoxypodophyllotoxin derivatives were synthesized and their anti-tumor effectiveness was evaluated. " 05/28/2019 - "Deoxypodophyllotoxin (DPT) is a cyclolignan compound that exerts anti-cancer effects against various types of cancers. "
3.	Glioma (Gliomas) 10/01/2023 - "Our previous study showed that deoxypodophyllotoxin (DPT), a natural compound isolated from the traditional herb Anthriscus sylvestris, triggered glioma cell death via parthanatos. " 09/01/2023 - "Evidence has shown that deoxypodophyllotoxin (DPT) induces parthanatos in glioma cells via induction of excessive ROS. " 09/01/2023 - "TAX1BP1 contributes to deoxypodophyllotoxin-induced glioma cell parthanatos via inducing nuclear translocation of AIF by activation of mitochondrial respiratory chain complex I." 02/28/2016 - "Therefore, we demonstrated that deoxypodophyllotoxin triggered parthanatos in glioma cells via induction of excessive ROS. " 02/28/2016 - "Deoxypodophyllotoxin triggers parthanatos in glioma cells via induction of excessive ROS."
4.	Carcinoma (Carcinomatosis) 08/01/2009 - "Structural studies revealed that it was deoxypodophyllotoxin (DPPT), and its biological activity was evaluated in HeLa human cervix carcinoma cells. "
5.	Glioblastoma (Glioblastoma Multiforme) 09/01/2023 - "[Retracted] Deoxypodophyllotoxin inhibits cell viability and invasion by blocking the PI3K/Akt signaling pathway in human glioblastoma cells." 03/01/2023 - "[Corrigendum] Deoxypodophyllotoxin inhibits cell viability and invasion by blocking the PI3K/Akt signaling pathway in human glioblastoma cells." 04/01/2019 - "Deoxypodophyllotoxin inhibits cell viability and invasion by blocking the PI3K/Akt signaling pathway in human glioblastoma cells." 04/01/2015 - "Antineoplastic effects of deoxypodophyllotoxin, a potent cytotoxic agent of plant origin, on glioblastoma U-87 MG and SF126 cells."

Related Drugs and Biologics

1.	Lignans
2.	Podophyllotoxin (Condylox)
3.	p38 Mitogen-Activated Protein Kinases
4.	Diterpenes
5.	Antineoplastic Agents (Antineoplastics)
6.	deoxypodophyllotoxin
7.	Tubulin Modulators
8.	Caspases
9.	Reactive Oxygen Species (Oxygen Radicals)
10.	Paclitaxel (Taxol)

Related Therapies and Procedures

1.	Therapeutics
2.	Chinese Traditional Medicine (Traditional Chinese Medicine)
3.	Drug Therapy (Chemotherapy)