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carbocyclic arabinosyladenine
structure
Also Known As:
C-ara-A; carbocyclic arabinofuranosyladenine; cyclaradine; cyclic arabinosyladenine
Networked:
3
relevant articles (
2
outcomes,
1
trials/studies)
Relationship Network
Bio-Agent Context: Research Results
Heterocyclic Compounds: 198
Fused-Ring Heterocyclic Compounds
2-Ring Heterocyclic Compounds
Purines: 651
Purine Nucleosides: 360
Adenosine: 12431
Vidarabine: 560
carbocyclic arabinosyladenine: 3
Nucleic Acids, Nucleotides, and Nucleosides: 1
Nucleosides: 6847
Purine Nucleosides: 360
Adenosine: 12431
Vidarabine: 560
carbocyclic arabinosyladenine: 3
Arabinonucleosides: 1
Vidarabine: 560
carbocyclic arabinosyladenine: 3
Related Diseases
1.
Herpes Genitalis (Genital Herpes)
09/30/1983 - "
Carbocyclic arabinofuranosyladenine (cyclaradine): efficacy against genital herpes in guinea pigs.
"
2.
Encephalitis (Encephalitis, Rasmussen)
10/01/1983 - "
Comparison of the efficacy of vidarabine, its carbocyclic analog (cyclaradine), and cyclaradine-5'-methoxyacetate in the treatment of herpes simplex virus type 1 encephalitis in mice.
"
3.
Herpesviridae Infections (Herpesvirus Infection)
10/01/1983 - "
Thus, cyclaradine or its 5'-methoxyacetic acid ester may possess some advantage over vidarabine in the treatment of severe herpesvirus infections and should therefore be considered for clinical trials in humans.
"
4.
Infections
10/01/1983 - "
The relative therapeutic effects of vidarabine (9-beta-D-arabinofuranosyladenine), cyclaradine (the adenosine deaminase-resistant carbocyclic analog of vidarabine), and cyclaradine-5'-methoxyacetate in the parenteral treatment of systemic herpes simplex virus type 1 infections in Swiss mice were determined.
"
09/30/1983 - "
Carbocyclic arabinofuranosyladenine (cyclaradine), a novel nucleoside analog with such desired features as hydrolytic and enzymatic stability, adenosine deaminase resistance, and low systemic toxicity, inhibited the replication of herpes simplex virus types 1 and 2. The 5'-methoxyacetate prodrug form exhibited significant efficacy in the topical treatment of genital infections by herpes simplex virus type 2.
"
5.
Drug-Related Side Effects and Adverse Reactions
10/01/1983 - "
Drug toxicity (measured by weight loss) was not detected in mice treated with cyclaradine or cyclaradine-5'-methoxyacetate at 750 mg/kg per day, whereas severe toxicity (weight loss of greater than or equal to 3 g) was observed in mice treated with vidarabine at an equivalent dose level.
"
Related Drugs and Biologics
1.
carbocyclic arabinosyladenine
2.
Vidarabine (Vira-A)
3.
cyclaradine-5'-methoxyacetate
4.
Esters
5.
Acids
6.
Adenosine Deaminase
7.
Therapeutic Uses
8.
Prodrugs
9.
Nucleosides