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bis(2-guanidinoethyl)disulfide

bifunctional cation; RN given refers to parent cpd; structure

Also Known As:

bis(2-guanidinoethyl)disulfide dihydrobromide; guanidinoethyldisulfide

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Amidines: 14
  - Guanidines: 29
    - bis(2-guanidinoethyl)disulfide: 3

Experts

1.	Szabó, Csaba: 3 articles (03/2006 - 03/2004)
2.	Southan, Garry J: 2 articles (03/2006 - 04/2004)
3.	Mabley, Jon G: 2 articles (04/2004 - 03/2004)
4.	Lohinai, Zsolt: 1 article (03/2006)
5.	Offenbacher, Steven: 1 article (03/2006)
6.	Paquette, David W: 1 article (03/2006)
7.	Rosenberg, Adam: 1 article (03/2006)
8.	Williams, Ray C: 1 article (03/2006)
9.	Bai, Peter: 1 article (04/2004)
10.	Goonesekera, Sunali: 1 article (04/2004)

Related Diseases

1.	Intestinal Polyposis (Polyposis, Intestinal) 04/14/2004 - "Pharmacological inhibition of inducible nitric oxide synthase (NOS) with guanidinoethyldisulfide (GED) or stimulation of the breakdown of the nitrogen reactive species peroxynitrite using a potent decomposition catalyst, FP 15, reduced both the intestinal tumor load and the oxidative stress associated with intestinal polyposis in Apc(min/+) mice. "
2.	Neoplasms (Cancer) 04/14/2004 - "Pharmacological inhibition of inducible nitric oxide synthase (NOS) with guanidinoethyldisulfide (GED) or stimulation of the breakdown of the nitrogen reactive species peroxynitrite using a potent decomposition catalyst, FP 15, reduced both the intestinal tumor load and the oxidative stress associated with intestinal polyposis in Apc(min/+) mice. "
3.	Hyperglycemia 03/01/2004 - "Here we demonstrate that guanidinoethyldisulfide (GED), a combined inducible nitric oxide synthase inhibitor and peroxynitrite/reactive oxygen species scavenger reduces the hyperglycemia and incidence of type I diabetes induced in mice by multiple low-dose streptozotocin treatment. "
4.	Gingivitis 03/01/2006 - "This masked, randomized, placebo-controlled preclinical investigation examined the effect of two mercaptoalkylguanidines, mercaptoethylguanidine (MEG) and guanidinoethyldisulfide (GED), which are iNOS inhibitors and reactive nitrogen scavenging compounds, on the development of experimental gingivitis in beagle dogs. "

Related Drugs and Biologics

1.	Nitric Oxide Synthase Type II (Inducible Nitric Oxide Synthase)
2.	Peroxynitrous Acid (Peroxynitrite)
3.	Nitrogen
4.	Reactive Oxygen Species (Oxygen Radicals)
5.	Streptozocin (Streptozotocin)
6.	2-mercaptoethylguanidine