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asperphenamate

isolated from culture filtrate & mycelium of Aspergillus flavipes ATCC 11013; structure

Also Known As:

N-benzoylphenylalanine-2-benzamido-3-phenyl propyl ester

Networked: 6 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Amino Acids: 30675
  - Essential Amino Acids: 1152
    - Phenylalanine: 4090
      - asperphenamate: 6
  - Cyclic Amino Acids: 3
    - Aromatic Amino Acids: 467
      - Phenylalanine: 4090
        asperphenamate: 6

Experts

1.	Ma, Enlong: 4 articles (02/2022 - 08/2012)
2.	Yuan, Lei: 4 articles (02/2022 - 08/2012)
3.	Li, Yanchun: 3 articles (02/2022 - 08/2012)
4.	Ge, Wentao: 2 articles (01/2019 - 12/2018)
5.	He, Wenhui: 2 articles (01/2019 - 12/2018)
6.	Hu, Baichun: 2 articles (01/2019 - 12/2018)
7.	Liu, Jun: 2 articles (01/2019 - 12/2018)
8.	Liu, Yang: 2 articles (01/2019 - 12/2018)
9.	Sheng, Lei: 2 articles (01/2019 - 12/2018)
10.	Wang, Jian: 2 articles (01/2019 - 12/2018)

Related Diseases

1.	Pancreatic Neoplasms (Pancreatic Cancer) 01/01/2023 - "Asperphenamate analog ASPER-29, which exhibits dual Cat L and S inhibitory potency, showed a definite antimetastatic effect on pancreatic cancer BxPC-3 and PANC-1 cells. " 02/01/2022 - "To develop a stronger antimetastatic agent, ASPER-29, a novel inhibitor of CATs designed by using the asperphenamate derivative BBP as a lead compound, was synthesized, and its therapeutic potential in pancreatic cancer metastasis was investigated in this study. "
2.	Neoplasm Metastasis (Metastasis) 02/01/2022 - "To develop a stronger antimetastatic agent, ASPER-29, a novel inhibitor of CATs designed by using the asperphenamate derivative BBP as a lead compound, was synthesized, and its therapeutic potential in pancreatic cancer metastasis was investigated in this study. "
3.	Breast Neoplasms (Breast Cancer) 12/01/2018 - "Due to its novel mechanism of action of inducing autophagy effects in breast cancer cells, asperphenamate has received our considerable attention. " 01/01/2019 - "Previous work in our group showed that TSA, as a synthetic analog of asperphenamate, induced autophagic cell death in breast cancer cells instead of apoptosis. " 08/15/2012 - "N-Benzoyl-O-(N'-(1-benzyloxycarbonyl-4-piperidiylcarbonyl)-D-phenylalanyl)-D-phenylalaninol (BBP), a novel synthesized asperphenamate derivative with the increased solubility, showed growth inhibitory effect on human breast carcinoma MCF-7 cells in a time- and concentration-dependent manner. "
4.	Constipation 11/01/2020 - "Rapid detection of asperphenamate in a hay batch associated with constipation and deaths in dairy cattle. "

Related Drugs and Biologics

1.	4-boronic acid benzophenone
2.	ASPER-29
3.	theasinensin A