|1.||Cao, Deliang: 2 articles (11/2011 - 07/2009)|
|2.||Kuhajda, F P: 2 articles (07/2001 - 01/2000)|
|3.||Pinn, M L: 2 articles (07/2001 - 01/2000)|
|4.||Wang, Shengpeng: 1 article (01/2015)|
|5.||Tan, Wen: 1 article (01/2015)|
|6.||Suo, Zhanwei: 1 article (01/2015)|
|7.||Yang, Xian: 1 article (01/2015)|
|8.||Wang, Yitao: 1 article (01/2015)|
|9.||Zhong, Zhangfeng: 1 article (01/2015)|
|10.||Hu, Xiaodong: 1 article (01/2015)|
08/01/2013 - "TOFA inhibited the proliferation of the cancer cells examined in a time‑ and dose‑dependent manner, arrested the cells in the G0/G1 cell cycle phase and induced apoptosis. "
08/01/2013 - "To the best of our knowledge, the present study demonstrated for the first time that TOFA inhibits COC1/DDP cell growth in ovarian tumor mouse xenografts. "
02/01/2008 - "In vitro studies in 3 different prostate tumor models (PC-3, LNCaP, and 22Rv1) demonstrated blocking of 1-(11)C-acetate accumulation after treatment with both C75 and TOFA. "
07/31/2009 - "Acetyl-CoA carboxylase-alpha inhibitor TOFA induces human cancer cell apoptosis."
11/01/2003 - "The continued ability of TOFA to rescue cancer cells from C75 cytotoxicity implies a proapoptotic role for malonyl-CoA independent of CPT-1 that selectively targets cancer cells as they progress into S phase."
|2.||Breast Neoplasms (Breast Cancer)
01/15/2000 - "Simultaneous exposure of breast cancer cells to TOFA and an FAS inhibitor resulted in significantly reduced cytotoxicity and apoptosis. "
01/01/2015 - "Berberine Regulated Lipid Metabolism in the Presence of C75, Compound C, and TOFA in Breast Cancer Cell Line MCF-7."
01/15/2000 - "In this study, inhibition of FA synthesis at the physiologically regulated step of carboxylation of acetyl-CoA to malonyl-CoA by 5-(tetradecyloxy)-2-furoic acid (TOFA) was not cytotoxic to breast cancer cells in clonogenic assays. "
07/13/2001 - "We have found that: [i] inhibition of FAS with cerulenin causes carnitine palmitoyltransferase-1 (CPT-1) inhibition and fatty acid oxidation inhibition in MCF-7 human breast cancer cells likely mediated by elevation of malonyl-CoA; [ii] cerulenin cytotoxicity is due to the nonphysiological state of increased malonyl-CoA, decreased fatty acid oxidation, and decreased fatty acid synthesis; and [iii] the cytotoxic effect of cerulenin can be mimicked by simultaneous inhibition of CPT-1, with etomoxir, and fatty acid synthesis with TOFA, an acetyl-CoA carboxylase (ACC) inhibitor. "
|3.||Ovarian Neoplasms (Ovarian Cancer)
08/01/2013 - "The aim of the present study was to investigate the effects of 5‑tetradecyloxy‑2‑furoic acid (TOFA), an allosteric inhibitor of ACC, on the proliferation and cell cycle progression of the ovarian cancer cell lines COC1 and COC1/DDP. "
08/01/2013 - "By inhibiting ACC, TOFA may be a promising small molecule agent for ovarian cancer therapy."
08/01/2013 - "TOFA suppresses ovarian cancer cell growth in vitro and in vivo."
|4.||Lung Neoplasms (Lung Cancer)
|1.||5-(tetradecyloxy)-2-furancarboxylic acid (TOFA)
|2.||Malonyl Coenzyme A (Malonyl CoA)
|3.||Acetyl Coenzyme A (Acetyl-CoA)
|6.||Janus Kinase 3
|7.||Peroxisome Proliferator-Activated Receptors (PPAR)
|9.||RNA (Ribonucleic Acid)
|10.||Dopamine Receptors (Dopamine Receptor)
|1.||Heterologous Transplantation (Xenotransplantation)