tocophersolan

RN given refers to parent cpd

Also Known As:

(+)-alpha-tocopheryl polyethylene glycol 1000 succinate; TPGS; TPGS 2K; alpha-D-tocopherol poly(ethylene glycol) 2000 succinate; alpha-tocopheryl polyethylene glycol succinate; mono-(2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-6-chromanyl) succinate polyethylene glycol monoester; poly(oxy-1,2-ethanediyl), alpha-(4-((3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-1-benzopyran-6-yl)oxy)-1,4-dioxobutyl-omega-hydroxy-; tocofersolan; tocopherol poly(ethylene glycol) 2000 succinate; tocopherol polyethylene glycol succinate; tocophersolan, (2R-(2R*(4R*,8R*)))-isomer; tocopheryl poly(ethylene glycol) 1000 succinate; vitamin E-TPGS; vitamine E PEG-1000-succinate

Networked: 419 relevant articles (62 outcomes, 100 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrans: 130
    - Benzopyrans: 195
      - Vitamin E: 8680
        tocophersolan: 419
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Benzopyrans: 195
      - Vitamin E: 8680
        tocophersolan: 419

Experts

1.	Mei, Lin: 23 articles (09/2019 - 05/2010)
2.	Feng, Si-Shen: 23 articles (10/2015 - 01/2006)
3.	Muthu, Madaswamy S: 18 articles (06/2021 - 12/2011)
4.	Zeng, Xiaowei: 18 articles (09/2018 - 10/2011)
5.	Huang, Laiqiang: 13 articles (09/2018 - 05/2010)
6.	Liu, Gan: 12 articles (09/2019 - 12/2011)
7.	Singh, Sanjay: 11 articles (01/2019 - 04/2013)
8.	Zhang, Zhiping: 9 articles (05/2020 - 01/2006)
9.	Tian, Yan: 9 articles (01/2018 - 05/2010)
10.	Gao, Meng: 8 articles (01/2020 - 01/2015)

Related Diseases

1.	Neoplasms (Cancer) 03/01/2018 - "In vivo studies of NDDS in tumor-bearing mice showed that DOX@MSNs-TPGS displayed better efficacy against MDR tumors in mice and reached the tumor site more effectively than DOX and DOX@MSNs, with minimal toxicity. " 01/01/2022 - "These findings strongly suggested that the multifunctional GO tumor-targeting drug delivery system RGD-TPGS-nGO-PTX could be used in clinical settings to improve PTX delivery, reverse MDR and increase the therapeutic efficacy of BC treatment." 04/01/2020 - "Moreover, the AuMSS functionalization improved the nanomaterials hemocompatibility and selectivity towards the cancer cells, particularly in the AuMSS-TPGS-HA (4:1) formulation. " 05/01/2014 - "Recently, it has been reported that TPGS acts as an anti-cancer agent alone or synergistically with chemotherapeutic drugs and increases the efficacy of nanoparticle formulations. " 01/01/2020 - "More importantly, the in vivo antitumor efficacy studies showed that HA-CHEMS-Cur-TPGS NPs greatly inhibited the tumor growth without resulting in obvious toxicities to major organs. "
2.	Lung Neoplasms (Lung Cancer) 07/01/2022 - "Afterward, the optimized GEF-NLC was engineered with TPGS (GEF-TPGS-NLC) and subjected to in vitro cytotoxicity, and apoptotic studies using the A549 cells line as a surrogate model for lung cancer. " 06/14/2023 - "The Early CDT®-Lung antibody blood test plus serial computed tomography scans for test-positives (TPGs) reduces late-stage lung cancer presentation. " 07/01/2022 - "Particularly, GEF-TPGS-NLC is a promising LDDS to increase the therapeutic outcomes of GEF during the treatment of metastatic lung cancer." 12/01/2015 - "PTX-MM exhibits obvious cytotoxicity against lung cancer cells with much lower IC50 value when compared with commercial formulated PTX or PTX + TPGS. " 05/15/2015 - "The concurrent delivery of AVT with TPGS in solid SMEDDS greatly enhanced the cytotoxic activity on lung cancer cells."
3.	Breast Neoplasms (Breast Cancer) 07/20/2021 - "The obtained results suggested that EXE-TPGS-PLHNPs can be a promising platform for the controlled delivery of EXE for the effective treatment of breast cancer." 11/21/2023 - "In addition, cytotoxicity studies and cellular DOX uptake on the MDA-MB-231 breast cancer cell line depict higher cytotoxic and drug uptake potential with better hemocompatibility of DOX-LIPO+-TPGS with respect to DOX. " 05/17/2023 - "Therefore, this study aimed to develop RSV-loaded PCL nanoparticles using nanoprecipitation and investigate the effect of TPGS on the nanoparticles' physicochemical characteristics (particle size, zeta potential, encapsulation efficiency, morphology, and release rate) and biological effects on the 4T1 breast cancer cell line (cytotoxicity and cell uptake), in vitro and in vivo. " 05/01/2017 - "In vitro cytotoxicity study on MCF-7 breast cancer cells exhibited enhanced cytotoxicity of EXM by encapsulating in TPGS-PCLNPs. " 05/01/2014 - "In this study, we investigated the antitumor efficacy and the molecular mechanism of action of TPGS in breast cancer cell lines. "
4.	Cholestasis 09/01/2012 - "Biochemical FSV insufficiency is commonly observed in infants with BA and persistent cholestasis despite administration of a TPGS containing liquid multiple FSV preparation. " 12/01/2016 - "Oral Tocofersolan Corrects or Prevents Vitamin E Deficiency in Children With Chronic Cholestasis." 10/01/2009 - "Oral tocofersolan was more bioavailable than the reference formulation in children with chronic cholestasis and similarly bioavailable in cystic fibrosis. " 06/01/1993 - "Multicenter trial of d-alpha-tocopheryl polyethylene glycol 1000 succinate for treatment of vitamin E deficiency in children with chronic cholestasis." 12/01/1987 - "TPGS appears to be a safe and effective form of orally administered vitamin E for use in children with chronic cholestasis who are unresponsive to available oral preparations of vitamin E."
5.	Colonic Neoplasms (Colon Cancer) 01/01/2019 - "Our results suggest that TPGS/CCM may increase therapeutic efficacy of CCM against colon cancer and merits further investigation in a clinical setting." 01/01/2019 - "These TPGS/CCM nanoparticles were shown to decrease intracellular ROS levels and apoptosis and inhibited migration of HT-29 human colon cancer cells more potently than free CCM. " 01/08/2018 - "The findings from this study provide novel insights into the use of TPGS and lipid nanoparticle together for the better antitumor effect in colon cancers. " 01/01/2019 - "Synthesis of TPGS/Curcumin Nanoparticles by Thin-Film Hydration and Evaluation of Their Anti-Colon Cancer Efficacy In Vitro and In Vivo." 01/08/2018 - "The presence of TPGS remarkably increased the anticancer effect of OXL in HT-29 colon cancer cells. "

Related Drugs and Biologics

1.	Micelles
2.	tocophersolan
3.	Succinic Acid (Succinate)
4.	polyethylene glycol 1000
5.	Paclitaxel (Taxol)
6.	Vitamin E
7.	Liposomes (Liposome)
8.	alpha-Tocopherol
9.	Docetaxel (Taxotere)
10.	Chitosan

Related Therapies and Procedures

1.	Therapeutics
2.	Drug Therapy (Chemotherapy)
3.	Intravenous Administration
4.	Intravenous Injections
5.	Precision Medicine