|1.||Paumgartten, Francisco J R: 2 articles (08/2009 - 01/2008)|
|2.||De-Oliveira, Ana C A X: 2 articles (08/2009 - 01/2008)|
|3.||Vinardell, María Pilar: 2 articles (12/2008 - 09/2004)|
|4.||Clapés, Pere: 2 articles (12/2008 - 09/2004)|
|5.||Infante, María Rosa: 2 articles (12/2008 - 09/2004)|
|6.||Benavides, Tomas: 2 articles (12/2008 - 09/2004)|
|7.||Mitjans, Montserrat: 2 articles (12/2008 - 09/2004)|
|8.||Clothier, Richard: 2 articles (12/2008 - 09/2004)|
|9.||Rho, Tae Ho D: 1 article (11/2014)|
|10.||Kim, Julie: 1 article (11/2014)|
08/15/2009 - "In this study we found that activities of ethoxy- and benzyloxy-resorufin-O-dealkylases, p-nitrophenol-hydroxylase and erythromycin-N-demethylase (mediated by CYP1A, 2B, 2E1 and 3A, respectively) were depressed, while uridine-glucuronosyl-transferase (a phase 2 enzyme) was unaltered in liver microsomes of Plasmodium berghei-infected (parasitemia >20%) male Swiss Webster mice. "
07/01/1999 - "When these activities were expressed per gm/liver (to account for the starvation-induced changes in liver microsomal protein), chlorzoxazone 6-hydroxylase activity doubled over control during starvation but ethoxy-resorufin-O-deethylase was not significantly changed. "
07/01/1999 - "Ethoxy-resorufin-O-deethylase activity (pmol/min/mg microsomal protein) was reduced with starvation, chlorzoxazone 6-hydroxylase activity (pmol/min per mg microsomal protein) initially decreased but then increased over controls. "
07/01/1999 - "Starvation has been previously demonstrated to induce CYP2E1 activity (assayed as chlorzozazone-6-hydroxylase activity) in mammals and this study was undertaken to determine the effects of starvation on liver chlorzozaxone-6-hydroxylase and ethoxy-resorufin-O-deethylase activity (a CYP1A1 activity) in juvenile winter flounder liver microsomes. "
07/01/1999 - "The effects of starvation on liver microsomal chlorzoxazone 6-hydroxylase and ethoxy-resorufin-O-deethylase activities are discussed in the context of the impact of physiological states on the ability of fish to detoxify marine xenobiotics."
|3.||Body Weight (Weight, Body)
03/01/1993 - "The induction of hepatic P450 2B protein and ethoxy-, pentoxy-, and (benzyloxy)resorufin O-dealkylation activities, and epoxide hydration activity and liver/body weight ratio increase were examined in male F344/NCr rats fed the various congeners for 14 days at doses equimolar to 500 ppm phenobarbital. "
01/01/1991 - "4. The microsomes contained about 43 pmol P-450/mg protein corresponding to 0.51 nmol P-450/g midgut and 64 pmol P-450/g body weight, respectively, and converted benzyloxyresorufin into resorufin with a Vmax of 2.12 pmol resorufin/min.mg protein and a Km of 770 nM benzyloxyresorufin at 25 degrees C, pH 8.0. "
03/01/2004 - "Increased liver-to-body weight ratios coincided with a significant induction of uridinediphosphate-glucuronosyltransferase (UDGPT; two to four-fold), and ethoxy- and pentoxy-resorufin-O-deethylase (EROD and PROD) at the two highest doses in all exposures. "
01/15/1990 - "In the guinea pig, 5 days after treatment with TCDD at 10 micrograms/kg, TCDD toxicity was also evident (loss of body weight and thymus weight); there was no change in DT-diaphorase as measured by resorufin reduction, confirming by a different assay the observation of Beatty and Neal (Biochem Pharmacol 27: 505-510, 1978) that TCDD does not induce DT-diaphorase in guinea pig liver, and 7-EROD was increased 8-fold. "
|4.||Hepatocellular Carcinoma (Hepatoma)
10/01/2003 - "The ethoxy resorufin-O-deethylase (EROD) induction with a micro-EROD assay in vitro using H4-IIE rat hepatoma cell cultures demonstrated the presence of persistent organics in influent and sequency effluents. "
10/15/2009 - "In a proof-of-concept experiment, the cytochrome P450 1A1/1A2 activity of a hepatoma cell line (HepG2/C3A) was monitored by measuring the enzymatic conversion of ethoxyresorufin to resorufin. "
01/01/2010 - "Using specific resorufin derivatives as substrates in vitro, the concentration of meso-zeaxanthin needed for 50 % inhibition of CYP1A2 (7-methoxyresorufin-O-demethylase) was 5 µg/ml, for CYP2B 1/2 (7- pentoxyresorufin-O-depentylase) was 8 µg/ml and for CYP1A1 (7-ethoxyresorufin-O-deethylase) was 12 µg/ml, while that of CYP 2E1 (aniline hydroxylase) was 7µg/ml and for CYP 1A, 2A, 2B, 2D and 3A (aminopyrene-N-demethylase) was 10.5 µg/ml. Evaluated using nitroso diethyl amine (NDEA) induced hepatocellular carcinoma in rats, treatment with meso-zeaxanthin reduced the tumor incidence when compared to the control group. "
|5.||Phototoxic Dermatitis (Phototoxicity)
12/01/2008 - "The potential phototoxicity which could result in irritant products, was determined by modulated cytotoxicity via the resazurin reduction to resorufin and neutral red uptake (NRU) endpoints. "
05/03/2004 - "Two immortalized cell lines, murine fibroblast cell line, 3T3, and one human keratinocyte cell line, HaCaT, were used as in vitro models to predict the potential phototoxicity which could result in irritation, determined by resazurin reduction to resorufin and neutral red uptake (NRU). "
|1.||Cytochrome P-450 CYP1A1 (CYP1A1)
|2.||Cytochrome P-450 CYP3A
|3.||Cytochrome P-450 CYP2E1 (CYP2E1)
|8.||Cytochrome P-450 CYP2B1 (PROD)