|1.||Jig, Chang-Jiu: 1 article (09/2011)|
|2.||Han, Hong-Jin: 1 article (09/2011)|
|3.||He, Wen-Jun: 1 article (09/2011)|
|4.||Zeng, Guang-Zhi: 1 article (09/2011)|
|5.||Tana, Ning-Hua: 1 article (09/2011)|
|6.||Akindahunsi, Afolabi Akintunde: 1 article (09/2011)|
|7.||Xu, Jun-Ju: 1 article (09/2011)|
|8.||Zhang, Yu-Mei: 1 article (09/2011)|
|9.||Adebayo, Abiodun Humphrey: 1 article (09/2011)|
01/01/1989 - "Precocene II (6,7-dimethoxy-2,2-dimethyl-2H-benzo[b]pyran), an insect growth regulator that is structurally related to several naturally occurring carcinogenic and non-carcinogenic alkenylbenzenes, is genotoxic and produces hepatic centrolobular necrosis in rats. "
04/01/1985 - "The proallatocidin precocene II (6,7-dimethoxy-2,2-dimethyl-2H-benzo-[b]pyran) has previously been shown to induce centrolobular liver necrosis. "
08/01/1987 - "These results indicate that the level of activity of various forms of cytochrome P-450 significantly influences the severity of hepatic necrosis induced by precocene II. Furthermore, these results suggest that inducible non-P-450 factors, such as glutathione S-transferases, may be important in modulating precocene II-induced hepatotoxicity."
09/01/2011 - "7,3',5'-Tri-O-methyltricetin (7), precocene II (9), 3,5,7,4'-tetrahydroxyflavone (13) and 5,6,7,3',4',5'-hexamethoxyflavone (14) exhibited inhibitory activity on the P-388 cancer cell line with IC50 values of 12.8, 24.8, 3.5 and 7.8 microM respectively, while compound 9 exhibited inhibitory activity on the HT-29 cancer cell line with an IC50 value of 61 microM; the others showed no significant cytotoxic activity on the cell lines tested."
|3.||Glutathione (Reduced Glutathione)
|4.||Cytochrome P-450 Enzyme System (Cytochrome P450)