HOMEPRODUCTSSERVICESCOMPANYCONTACTFAQResearchDictionaryPharmaMobileSign Up FREE or Login

neuromelanin

lipomelanoprotein pigment found in human locus caeruleus & substantia nigra; composed of eumelanin and pheomelanin
Networked: 190 relevant articles (1 outcomes, 15 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Zecca, Luigi: 14 articles (06/2014 - 01/2002)
2. Riederer, Peter: 9 articles (01/2011 - 01/2002)
3. Zucca, Fabio A: 8 articles (06/2014 - 08/2003)
4. Gerlach, Manfred: 8 articles (01/2011 - 01/2003)
5. Sulzer, David: 7 articles (01/2014 - 01/2002)
6. Zecca, L: 7 articles (01/2007 - 02/2000)
7. Sasaki, Makoto: 6 articles (07/2014 - 07/2006)
8. Riederer, P: 6 articles (12/2013 - 12/2001)
9. Segura-Aguilar, Juan: 5 articles (06/2014 - 10/2009)
10. Muñoz, Patricia: 5 articles (06/2014 - 10/2009)

Related Diseases

1. Parkinson Disease (Parkinson's Disease)
2. Parkinsonian Disorders (Parkinsonism)
3. Alzheimer Disease (Alzheimer's Disease)
4. Gliosis
03/01/1996 - "Four of the six patients with nigral Lewy bodies showed severe loss of neural cell bodies, reactive astrocytosis, gliosis and neuromelanin in macrophages and in the neuropile. "
01/01/1991 - "Our findings are unusual in that there was marked gliosis of the substantia nigra with a large amount of free extracellular neuromelanin despite a 3-year clinical course. "
01/01/1986 - "Autopsy studies in 8 girls with the Rett syndrome dying between 4 and 15 years showed: Diffuse cerebral atrophy/micrencephaly, with a decrease in brain weight by 13.8 to 33.8% of age-matched controls, apparently related to the duration of the disorder; Mild, but inconsistent diffuse cortical atrophy without developmental disorders apart from occasional microdysgenesis (three cases), but increased amounts of neuronal lipofuscin, and occasional mild astrocytic gliosis; Mild, but inconsistent spongy changes in cerebral and cerebellar white matter, optic nerve (two cases), and myelinated fascicles of the brainstem tegmentum, without signs of dys- or demyelination, and apparently different from the spongy myelinopathy common to aminoacidopathies; Most conspicuous was an underpigmentation of the substantia nigra which contained many fewer well-pigmented neurons for age (53-73%), and fewer pigmented granules per neuron, while the total number of nigral neurons and the triphasic substructure of neuromelanin were normal for age. "
01/01/1988 - "Autopsy studies in nine girls dying between 4 and 17 years, and sural nerve and muscle biopsies from two girls aged 3 and 17 years showed: (1) diffuse cortical atrophy/micrencephaly, with a decrease in brain weight by 12% to 34% of age-matched controls, apparently related to the duration of the disorder; (2) mild diffuse cortical atrophy with increased amounts of neuronal lipofuscin and occasional mild gliosis, but without signs of a storage disorder; (3) underpigmentation of the zona compacta nigrae, which showed fewer well-pigmented neurons for age and fewer melanin granules per neuron, while total numbers of nigral neurons and the substructure of neuromelanin were normal for age. "
5. Atrophy
01/01/1986 - "Autopsy studies in 8 girls with the Rett syndrome dying between 4 and 15 years showed: Diffuse cerebral atrophy/micrencephaly, with a decrease in brain weight by 13.8 to 33.8% of age-matched controls, apparently related to the duration of the disorder; Mild, but inconsistent diffuse cortical atrophy without developmental disorders apart from occasional microdysgenesis (three cases), but increased amounts of neuronal lipofuscin, and occasional mild astrocytic gliosis; Mild, but inconsistent spongy changes in cerebral and cerebellar white matter, optic nerve (two cases), and myelinated fascicles of the brainstem tegmentum, without signs of dys- or demyelination, and apparently different from the spongy myelinopathy common to aminoacidopathies; Most conspicuous was an underpigmentation of the substantia nigra which contained many fewer well-pigmented neurons for age (53-73%), and fewer pigmented granules per neuron, while the total number of nigral neurons and the triphasic substructure of neuromelanin were normal for age. "
01/01/1988 - "Autopsy studies in nine girls dying between 4 and 17 years, and sural nerve and muscle biopsies from two girls aged 3 and 17 years showed: (1) diffuse cortical atrophy/micrencephaly, with a decrease in brain weight by 12% to 34% of age-matched controls, apparently related to the duration of the disorder; (2) mild diffuse cortical atrophy with increased amounts of neuronal lipofuscin and occasional mild gliosis, but without signs of a storage disorder; (3) underpigmentation of the zona compacta nigrae, which showed fewer well-pigmented neurons for age and fewer melanin granules per neuron, while total numbers of nigral neurons and the substructure of neuromelanin were normal for age. "

Related Drugs and Biologics

1. Complement System Proteins (Complement)
2. Iron
3. Lipofuscin
4. Melanins (Melanin)
5. Manganese
6. Tyrosine 3-Monooxygenase (Tyrosine Hydroxylase)
7. Aluminum
8. Dopamine (Intropin)
9. alpha-Synuclein
10. Ions

Related Therapies and Procedures

1. Boron Neutron Capture Therapy
2. Denervation