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mannonate

labeled with Tc 99m; used in renal scanning

Networked: 5 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Carboxylic Acids: 973
  - Hydroxy Acids: 94
    - Sugar Acids: 4
      - mannonate: 5
  - Acyclic Acids
    - Sugar Acids: 4
      - mannonate: 5
Carbohydrates: 22023
- Sugar Acids: 4
  - mannonate: 5

Experts

1.	Almo, Steven C: 3 articles (09/2014 - 11/2007)
2.	Gerlt, John A: 3 articles (09/2014 - 11/2007)
3.	Wichelecki, Daniel J: 2 articles (09/2014 - 04/2014)
4.	Fedorov, Alexander A: 2 articles (04/2014 - 11/2007)
5.	Fedorov, Elena V: 2 articles (04/2014 - 11/2007)
6.	Al-Obaidi, Nawar: 1 article (09/2014)
7.	Jones, Amy M: 1 article (09/2014)
8.	Vendiola, Jean Alyxa Ferolin: 1 article (09/2014)
9.	Balthazor, Bryan M: 1 article (04/2014)
10.	Chau, Anthony C: 1 article (04/2014)

Related Diseases

1.

Dehydration (Water Stress)

11/13/2007 - "Structures of the wild type ManD from Novosphingobium aromaticivorans were determined at pH 7.5 in the presence of Mg2+ and also in the presence of Mg2+ and the 2-keto-3-keto-d-gluconate dehydration product; the structure of the catalytically active K271E mutant was determined at pH 5.5 in the presence of the d-mannonate substrate. "
09/09/2014 - "That study revealed that members of the ManD subgroup vary in substrate specificity and catalytic efficiency: high-efficiency (kcat/KM = 10(3)-10(4) M(-1) s(-1)) for dehydration of D-mannonate, low-efficiency (kcat/KM = 10-10(2) M(-1) s(-1)) for dehydration of D-mannonate and/or D-gluconate, and no activity. "
04/29/2014 - "Previously, one member of the subgroup had been experimentally characterized as ManD [dehydration of D-mannonate to 2-keto-3-deoxy-D-mannonate (equivalently, 2-keto-3-deoxy-D-gluconate)]. "
11/01/2012 - "Mannonate dehydratase (ManD; EC4.2.1.8) catalyzes the dehydration of D-mannonate to 2-keto-3-deoxygluconate. "
09/01/2009 - "ManD catalyzes the dehydration of d-mannonate to yield 2-keto-3-deoxygluconate (2-KDG), the carbon and energy source for growth. "

Related Drugs and Biologics

1.	gluconic acid (gluconate)
2.	2-keto-3-deoxygluconate
3.	Carbon
4.	Acids
5.	Sugars
6.	mannonate dehydratase