|1.||Evangelista, Stefano: 3 articles (09/2008 - 12/2002)|
|2.||Lee, Kwang Jae: 2 articles (10/2015 - 01/2014)|
|3.||Clavé, Pere: 2 articles (07/2014 - 02/2014)|
|4.||Tack, Jan: 2 articles (02/2014 - 03/2013)|
|5.||Boeckxstaens, Guy: 2 articles (02/2014 - 03/2013)|
|6.||Corazziari, Enrico S: 2 articles (02/2014 - 03/2013)|
|7.||Chang, Full-Young: 2 articles (01/2012 - 10/2011)|
|8.||Cipriani, G: 1 article (07/2015)|
|9.||Faussone-Pellegrini, M S: 1 article (07/2015)|
|10.||Sha, L: 1 article (07/2015)|
|1.||Irritable Bowel Syndrome (Syndrome, Irritable Bowel)
01/01/2012 - "Is Otilonium Bromide Really Effective for Treating Asian Patients With Irritable Bowel Syndrome?: Author's Reply."
01/01/2012 - "Is otilonium bromide really effective for treating asian patients with irritable bowel syndrome?"
10/01/2011 - "Is otilonium bromide globally effective in irritable bowel syndrome?"
10/01/1998 - "To evaluate the efficacy of otilonium bromide, a spasmolytic agent, in the treatment of irritable bowel syndrome using modern and validated diagnostic criteria. "
09/14/2014 - "Otilonium bromide in irritable bowel syndrome: a dose-ranging randomized double-blind placebo-controlled trial."
|2.||Abdominal Pain (Pain, Abdominal)
11/01/1991 - "In group B otilonium bromide induced a significant improvement (p less than 0.01) of abdominal pain and distension when comparing T0 with T24. "
01/01/2007 - "Otilonium bromide, a spasmolytic agent, has been widely used worldwide and has been found to be effective and safe for managing abdominal pain. "
10/01/1992 - "Seventy-two patients complaining mainly of abdominal pain were studied in a double-blind trial (octylonium bromide 40 mg tid for 4 weeks or placebo). "
11/01/1991 - "Seventy-two patients complaining of abdominal pain were studied in a double blind trial with otilonium bromide (OB) (40 mg tid or placebo). "
08/01/2011 - "This placebo-controlled double-blind study shows that otilonium bromide is safe, well tolerated and superior to placebo in reducing the frequency of abdominal pain, severity of abdominal bloating and protecting from symptom relapse in IBS. "
01/01/2001 - "Otilonium bromide was developed to block smooth muscle Ca release to control cramping pain of these patients. "
10/01/1992 - "In contrast to placebo, octylonium bromide significantly reduced pain and bloating, and significantly increased (p < 0.02) the pain threshold throughout the treatment period. "
12/01/2002 - "The present re-evaluation of a previously published study confirms that otilonium bromide is more effective than placebo for the treatment of irritable bowel syndrome, being very efficient in relieving pain and discomfort."
03/01/2013 - "THE OBIS TRIAL: The recent large placebo-controlled Otilonium Bromide in Irritable Bowel Syndrome study demonstrated the superiority of otilonium bromide versus placebo not only in the reduction of pain and bloating, but also in protection from relapse due to the long-lasting effect."
12/01/2002 - "The total monthly and weekly responses to the single endpoints (intensity and frequency of pain and discomfort, meteorism/abdominal distension, severity of diarrhoea or constipation and mucus in the stool) were significantly more frequent in the group treated with otilonium bromide than in the placebo-treated group, with differences ranging from 10% to 20%. "
|4.||Anxiety Disorders (Anxiety Disorder)
|5.||Muscle Spasticity (Spastic)
01/14/1984 - "The effectiveness of a new calmodulin-independent spasmolytic, tiropramide hydrochloride, and octylonium bromide, an antispasmodic calmodulin-antagonist drug, was compared in a controlled trial performed in 60 patients with irritable bowel syndrome with spastic pattern. "
01/01/1997 - "Otilonium bromide is a calcium antagonist with a direct myolytic effect, that is indicated in spastic conditions and functional dyskinesias of the gastroenteric apparatus (irritable bowel syndrome) and as a premedication for gastrointestinal endoscopic procedures. "
|2.||octylonium (otilonium bromide)
|8.||Calmodulin (Calcium-Dependent Activator Protein)
|9.||DA 3177 (cimetropium)