etoprine (DDEP)

do not confuse with 3,5-dicarbethoxy-2,6-dimethyl-4-ethyl-1,4-dihydropyridine, also called DDEP

Also Known As:

DDEP; BW 2760; ethodichlorophen; 2,4-diamino-5- (3',4'-dichlorophenyl)-6-ethylpyrimidine

Networked: 4 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrimidines: 510
    - Pyrimethamine: 1391
      - etoprine: 4

Related Diseases

1.	Leukemia 08/15/1989 - "A selected number of 1,3-diaminobenzo[f]quinazolines and 1,3-diamino-5,6-dihydrobenzo[f]quinazolines, which may be viewed as tricyclic analogues of the lipid-soluble antifolates pyrimethamine (PM), metoprine (DDMP), and etoprine (DDEP), were tested as inhibitors of purified dihydrofolate reductase (DHFR) from WI-L2 lymphoblasts, and as inhibitors of the growth of Streptococcus faecium ATCC 8043 and L1210 murine leukemia cells in culture. "
2.	Infertility (Sterility) 03/01/1995 - "We found that of the compounds tested, etoprine is a potent antifertility agent that causes complete infertility at doses of > or = 5 mg/kg/day in mice with a threshold of effectiveness occurring between 1 and 5 mg/kg/day. "
3.	Hypertension (High Blood Pressure) 08/01/1995 - " Other avenues of research are focusing on nifedipine, a drug used to treat high blood pressure, on mifepristone (RU-486) which temporarily blocks calcium, and on etoprine, which suppresses rapidly dividing sperm cells. "
4.	Glioma (Gliomas) 01/01/1982 - "When animals bearing ASV-induced gliomas were treated with DDMP or etoprine with or without citrovorum factor (calcium leucovorin), there was no increase in survival, even though the drugs were administered at maximally tolerated doses." 01/01/1982 - "Evaluation of the lipid-soluble diaminopyrimidines, metoprine and etoprine, in the avian sarcoma virus rat glioma model." 01/01/1982 - "Using the avian sarcoma virus (ASV) rat glioma model, we have evaluated the in vivo effectiveness of two lipid-soluble folate antagonists, metoprine (DDMP) and its 6-ethyl analog etoprine. "

Related Drugs and Biologics

1.	Lipids
2.	etoprine (DDEP)
3.	metoprine
4.	Mifepristone (RU 486)
5.	Tetrahydrofolate Dehydrogenase (Dihydrofolate Reductase)
6.	Quinazolines
7.	Pyrimethamine (Daraprim)
8.	Nifedipine (Adalat)
9.	Folic Acid Antagonists
10.	Folic Acid (Vitamin M)