Also Known As:
1-(2-chloroethyl)-1-nitroso-3-(2-hydroxyethyl)urea; 1-(2-hydroxyethyl)-3-(2-chloroethyl)-3-nitrosourea; 2-chloroethyl-1-nitrosureidoethanol; CNU-ethanol; HECNU; NSC 29485
Networked: 16 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Related Diseases

1. Melanoma (Melanoma, Malignant)
2. Glioma (Gliomas)
3. Neoplasms (Cancer)
4. Carcinoma (Carcinomatosis)
01/01/1989 - "The combination treatment of hormone-dependent autochthonous mammary carcinomas in the rat with nicotine plus HECNU, a water-soluble nitrosourea, resulted in a potentiation of antitumor action. "
01/01/1988 - "In MNU-induced autochthonous mammary carcinoma, a solid hormone-dependent tumor, the combination of HECNU and nicotine yielded greater tumor inhibition than HECNU alone. "
01/01/1986 - "Female Sprague-Dawley rats bearing methylnitrosourea-induced mammary carcinomas were treated with 100 mumol 1-(2-hydroxyethyl)-3-(2-chloroethyl)-3-nitrosourea (HECNU)/kg to investigate the time course of DNA-DNA interstrand cross-linking (DNA-XL) as measured by alkaline elution in tumor, bone marrow and liver cells. "
01/01/1991 - "(A) by chemical modifications such as: (1) exchanging a chlorine atom in N, N'-bis-(2-chloroethyl)-N-nitrosourea (BCNU) in the chloroethyl group at N'-position for a hydroxyl group to form the less carcinogenic analog N-(2-chloroethyl)-N'-(2-hydroxyethyl)-N-nitrosourea (HECNU); (2) linking chlorambucil to the steroid prednisolone to obtain a conjugate (prednimustine) with distinctly lower carcinogenic potential than chlorambucil; (3) progressive ring halogenation of phenyl-triazenes to generate agents with decreased long-term toxic risk; (B) by replacing cyclophosphamide within the carcinogenic drug combination of cyclophosphamide, methotrexate and 5-fluorouracil (CMF) by vincristine to form the combination VMF which has no detectable carcinogenic potential; (C) by coadministration of cyclophosphamide and mesna to achieve a dose-related reduction of cyclophosphamide-induced urinary bladder carcinomas; (D) by administration of dinaline, a compound which reduces the spontaneous incidence of malignant tumors in rats. "
5. Parasitemia

Related Drugs and Biologics

1. Carmustine (FIVB)
2. 1-(2-chloroethyl)-1-nitrosourea (CNU)
3. chlorozotocin
4. Semustine
5. Lomustine (CCNU)
6. elmustine
7. Urea (Carbamide)
8. Nicotine
9. Hormones
10. DNA (Deoxyribonucleic Acid)

Related Therapies and Procedures

1. Heterologous Transplantation (Xenotransplantation)
2. Drug Therapy (Chemotherapy)
3. Radiotherapy