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benzylidene glucose
Also Known As:
4,6-benzylidene-D-glucose; P-1013; benzylidene glucopyranose; alpha-D-Glucopyranose, 4,6-O-(phenylmethylene)-
Networked:
5
relevant articles (
1
outcomes,
0
trials/studies)
Relationship Network
Bio-Agent Context: Research Results
Carbohydrates: 22023
Sugars: 11126
Monosaccharides: 889
Hexoses: 549
Glucose: 147007
benzylidene glucose: 5
Related Diseases
1.
Carcinoma (Carcinomatosis)
06/01/1995 - "
P-1013 at 90 mg/kg for 49 days was effective against SK-OV-3 human ovarian carcinoma (T/C 47% at day 40 and 50% increase in TD).
"
2.
Neoplasms (Cancer)
06/01/1995 - "
It is possible that P-1013, in addition to inhibiting the rate of tumor volume growth, also induces tumor necrotization in the ovarian xenograft.
"
01/01/1995 - "
We conclude that the pharmacokinetics of P-1013 does not prevent its use as a cancer treatment drug given orally.
"
06/01/1995 - "
Histological examinations of each tumor showed that P-1013 treatment of pancreatic xenografts reduced tumor volume without inducing greater necrosis than that comparable to respective control tumors.
"
06/01/1995 - "
4,6-Benzylidene-d1-D-glucose, P-1013, a deuterated benzaldehyde derivative which acts as a reversible protein synthesis inhibitor in vitro, was evaluated for antitumor effects in two human tumor xenografts implanced s.c.
"
3.
Body Weight (Weight, Body)
05/01/1990 - "
In vivo pharmacokinetics of 4,6-benzylidene-D-glucose (BG) was investigated in rats following an i.v. bolus injection of 85 mg BG/kg body weight.
"
03/01/1986 - "
The effect of 4,6-benzylidene-D-glucose (BG) on chemically induced primary hepatocellular carcinomas in rats was tested after daily single injections of 85 mg per kg body weight into the aorta through a canula implanted through the right carotid artery.
"
4.
Pancreatic Neoplasms (Pancreatic Cancer)
06/01/1995 - "
P-1013 at 90 mg/kg also suppressed growth of PANC-1 human pancreatic carcinoma in two experiments (T/C 44 and 50%, 20 and 40% increase in TD, respectively).
"
5.
Necrosis
06/01/1995 - "
Histological examinations of each tumor showed that P-1013 treatment of pancreatic xenografts reduced tumor volume without inducing greater necrosis than that comparable to respective control tumors.
"
Related Drugs and Biologics
1.
Protein Synthesis Inhibitors
2.
benzaldehyde
Related Therapies and Procedures
1.
Injections