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benzylidene glucose

Also Known As:

4,6-benzylidene-D-glucose; P-1013; benzylidene glucopyranose; alpha-D-Glucopyranose, 4,6-O-(phenylmethylene)-

Networked: 5 relevant articles (1 outcomes, 0 trials/studies)

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Bio-Agent Context: Research Results

Carbohydrates: 22023
- Sugars: 11126
  - Monosaccharides: 889
    - Hexoses: 549
      - Glucose: 147007
        benzylidene glucose: 5

Related Diseases

1.	Carcinoma (Carcinomatosis) 06/01/1995 - "P-1013 at 90 mg/kg for 49 days was effective against SK-OV-3 human ovarian carcinoma (T/C 47% at day 40 and 50% increase in TD). "
2.	Neoplasms (Cancer) 06/01/1995 - "It is possible that P-1013, in addition to inhibiting the rate of tumor volume growth, also induces tumor necrotization in the ovarian xenograft." 01/01/1995 - "We conclude that the pharmacokinetics of P-1013 does not prevent its use as a cancer treatment drug given orally." 06/01/1995 - "Histological examinations of each tumor showed that P-1013 treatment of pancreatic xenografts reduced tumor volume without inducing greater necrosis than that comparable to respective control tumors. " 06/01/1995 - "4,6-Benzylidene-d1-D-glucose, P-1013, a deuterated benzaldehyde derivative which acts as a reversible protein synthesis inhibitor in vitro, was evaluated for antitumor effects in two human tumor xenografts implanced s.c. "
3.	Body Weight (Weight, Body) 05/01/1990 - "In vivo pharmacokinetics of 4,6-benzylidene-D-glucose (BG) was investigated in rats following an i.v. bolus injection of 85 mg BG/kg body weight. " 03/01/1986 - "The effect of 4,6-benzylidene-D-glucose (BG) on chemically induced primary hepatocellular carcinomas in rats was tested after daily single injections of 85 mg per kg body weight into the aorta through a canula implanted through the right carotid artery. "
4.	Pancreatic Neoplasms (Pancreatic Cancer) 06/01/1995 - "P-1013 at 90 mg/kg also suppressed growth of PANC-1 human pancreatic carcinoma in two experiments (T/C 44 and 50%, 20 and 40% increase in TD, respectively). "
5.	Necrosis 06/01/1995 - "Histological examinations of each tumor showed that P-1013 treatment of pancreatic xenografts reduced tumor volume without inducing greater necrosis than that comparable to respective control tumors. "

Related Drugs and Biologics

1.	Protein Synthesis Inhibitors
2.	benzaldehyde

Related Therapies and Procedures

1.	Injections