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alpha 2u globulin
androgen-dependent rat urinary protein; synthesized by hepatic tissue; released into plasma & filtered through kidneys into urine
Also Known As:
alpha(2mu)-globulin; alpha2mu-globulin; alpha2u globulin
Networked:
7
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Amino Acids, Peptides, and Proteins: 1
Proteins: 484843
Blood Proteins: 12459
Serum Globulins: 553
Alpha-Globulins: 100
alpha 2u globulin: 7
Globulins: 3062
Serum Globulins: 553
Alpha-Globulins: 100
alpha 2u globulin: 7
Experts
1.
Lock, Edward A
: 1 article (06/2006)
2.
Reed, Celia J
: 1 article (06/2006)
3.
Lash, L H
: 1 article (06/2001)
4.
Parker, J C
: 1 article (06/2001)
Related Diseases
1.
Neoplasms (Cancer)
06/01/2006 - "
34, 211-299) of chemicals that induce renal tubule tumors, we found no clear evidence to place TCE in category 1 or 2 (chemicals that directly or indirectly interact with renal DNA), category 4 (direct cytotoxicity and sustained tubule cell regeneration), category 5 (indirect cytotoxicity and sustained tubule cell regeneration associated with alpha2u-globulin accumulation), or category 6 (exacerbation of spontaneous chronic progressive nephropathy).
"
01/01/1999 - "
Possible mechanisms of induction of renal tubule cell neoplasms in rats associated with alpha 2u-globulin: role of protein accumulation versus ligand delivery to the kidney.
"
2.
Carcinogenesis
06/01/2001 - "
Four potential modes of action for Perc-induced renal tumorigenesis are: 1) peroxisome proliferation, 2) alpha-2u-globulin nephropathy, 3) genotoxicity leading to somatic mutation, and 4) acute cytotoxicity and necrosis leading to cell proliferation.
"
3.
Nephrosis
05/01/1987 - "
Dose-related hyaline droplet formation associated with renal accumulation of a specific protein alpha 2u-globulin) is considered the primary response in the morphogenesis of decalin-induced nephrotoxicity in the male rat and was present to a maximal degree in all decalin- and d-limonene-treated groups by day 6. Alterations considered to be sequelae of the hyaline droplet response, including granular casts in the outer zone of the medulla and multiple cortical changes collectively classified as chronic nephrosis, were present in the kidneys of both decalin- and d-limonene-treated rats killed on day 27.
"
4.
Necrosis
06/01/2001 - "
Four potential modes of action for Perc-induced renal tumorigenesis are: 1) peroxisome proliferation, 2) alpha-2u-globulin nephropathy, 3) genotoxicity leading to somatic mutation, and 4) acute cytotoxicity and necrosis leading to cell proliferation.
"
5.
Hepatocellular Carcinoma (Hepatoma)
03/25/1982 - "
Modifications in alpha 2u globulin gene structure, transcription, and mRNA translation in hepatomas.
"
03/25/1982 - "
In hepatoma 5123D, however, a small number of alpha 2u globulin RNA sequences were detected by Northern blot and R0t analysis, but this RNA was not detectably translationally active either in vivo or in an in vitro cell-free translational system.
"
03/25/1982 - "
No alpha 2u globulin mRNA was detected in hepatoma 7793 by cell-free translation, Northern blot, or R0t analysis.
"
03/25/1982 - "
We have compared the structure and transcription of the alpha 2u globulin genes in Morris hepatomas 5123D and 7793 with that of normal hepatic genes using alpha 2u globulin cDNA as a hybridization probe.
"
03/25/1982 - "
No structural differences between normal liver and the hepatoma alpha 2u globulin genes were observed by Southern blot analysis of genomic DNA digested with restriction endonucleases Pst I, Bam HI, or Ava I. However, a general demethylation of cytosine residues in the alpha 2u globulin genes of hepatomas has been found using the restriction enzyme Hha I and the isoschizomeric pair of restriction enzymes Msp I and Hpa II. Therefore, loss of the alpha 2u globulin phenotype in these hepatomas is accompanied by extensive demethylation of DNA sequences within and/or immediately flanking the alpha 2u globulin genes.
"
Related Drugs and Biologics
1.
Messenger RNA (mRNA)
2.
Proteins (Proteins, Gene)
3.
DNA (Deoxyribonucleic Acid)
4.
Complementary DNA (cDNA)
5.
Testosterone (Sustanon)
6.
RNA (Ribonucleic Acid)
7.
Ligands
8.
Gonadotropins
9.
Estrogens (Estrogen)
10.
Enzymes