|1.||Schirmbeck, Reinhold: 4 articles (01/2013 - 08/2007)|
|2.||Brosi, Helen: 3 articles (01/2013 - 12/2009)|
|3.||Spyrantis, Andreas: 3 articles (08/2010 - 08/2007)|
|4.||Rajasalu, Tarvo: 3 articles (08/2010 - 08/2007)|
|5.||Schuster, Cornelia: 2 articles (01/2013 - 08/2010)|
|6.||Boehm, Bernhard Otto: 2 articles (08/2010 - 12/2009)|
|7.||Afonso, Georgia: 1 article (10/2015)|
|8.||Kyewski, Bruno: 1 article (10/2015)|
|9.||Dimitrov, Jordan: 1 article (10/2015)|
|10.||Törn, C: 1 article (10/2015)|
11/30/2001 - "Adenovirus-mediated preproinsulin gene transfer into adipose tissues ameliorates hyperglycemia in obese diabetic KKA(y) mice."
07/01/2008 - "Alteration of pancreatic beta-cell survival and Preproinsulin gene expression by prolonged hyperglycemia may result from increased c-MYC expression. "
11/30/2001 - "We investigated whether adenovirus-mediated preproinsulin gene transfer into insulin target tissues (adipocytes) ameliorates hyperglycemia in diabetic mice. "
|2.||Experimental Diabetes Mellitus
|3.||Type 1 Diabetes Mellitus (Autoimmune Diabetes)
03/01/2015 - "Preproinsulin specific CD8+ T cells in subjects with latent autoimmune diabetes show lower frequency and different pathophysiological characteristics than those with type 1 diabetes."
08/01/2010 - "RIP-B7.1 mice expressing the costimulator molecule B7.1 (CD80) on pancreatic beta-cells are a well established model to characterize preproinsulin-specific CD8 T-cell responses and experimental autoimmune diabetes (EAD). "
01/01/2013 - "We established mouse models, expressing the costimulator molecule B7.1 (CD80) on pancreatic beta cells (RIP-B7.1 tg mice) or are deficient in coinhibitory PD-L1 or PD-1 molecules (PD-L1(-/-) and PD-1(-/-) mice), to study induction of preproinsulin (ppins)-specific CD8 T-cell responses and experimental autoimmune diabetes (EAD) by DNA-based immunization. "
10/01/2015 - "Materno-Fetal Transfer of Preproinsulin Through the Neonatal Fc Receptor Prevents Autoimmune Diabetes."
12/01/2009 - "Immunization of RIP-B7.1 mice with preproinsulin (ppins)-encoding plasmid DNA efficiently induces experimental autoimmune diabetes (EAD). "
05/01/1992 - "[Cloning, primary structure determination and expression of preproinsulin cDNA from human insulinoma in Escherichia coli]."
02/01/1984 - "Much of the E1A-induced preproinsulin mRNA had a 5' end at the same position as the preproinsulin mRNA isolated from insulinoma cells, but a considerable fraction had 5' ends mapping heterogeneously within several hundred nucleotides of this site. "
06/01/1981 - "S1 nuclease analysis revealed the presence of a correctly spliced coding segment of the preproinsulin transcript similar or identical in its electrophoretic mobility to that of messenger ribonucleic acid produced in rat insulinoma cells. "
03/09/1987 - "In HIT-T15 cells grown in the absence of glucose, Northern blot analysis of total RNA revealed a major 0.5 kb preproinsulin (ppI) mRNA transcript which co-migrated with the mature transcript from a human insulinoma. "
|5.||Islet Cell Adenoma (Islet Cell Tumors)
03/01/1978 - "A minor component having an apparent molecular weight of 11,100 was identified as preproinsulin by the sensitivity of its synthesis to glucose, the pattern of NH2-terminal leucine residues, and the rapidity of its appearance and disappearance during incubation of islets or islet cell tumors. "
10/01/1976 - "Electrophoretically homogeneous messenger RNA for rat preproinsulin has been prepared from an islet cell tumor by the use of oligo(dT(-cellulose chromatography and sucrose density gradient centrifugation. "
|1.||DNA (Deoxyribonucleic Acid)
|3.||Blood Glucose (Blood Sugar)
|4.||Messenger RNA (mRNA)
|5.||RNA (Ribonucleic Acid)
|6.||Glutamate Decarboxylase (Decarboxylase, Glutamate)
|9.||beta-Globins (beta Globin)
|10.||Proglucagon (Glucagon Precursors)