|1.||Sarang, S: 2 articles (06/2013 - 02/2012)|
|2.||Bus, J: 2 articles (06/2013 - 02/2012)|
|3.||Banton, M: 2 articles (06/2013 - 02/2012)|
|4.||Cruzan, G: 2 articles (06/2013 - 02/2012)|
|5.||Hotchkiss, J: 2 articles (06/2013 - 02/2012)|
|6.||Carlson, Gary P: 2 articles (12/2008 - 06/2002)|
|7.||Li, Lei: 1 article (01/2014)|
|8.||Shen, Shuijie: 1 article (01/2014)|
|9.||Ding, Xinxin: 1 article (01/2014)|
|10.||Zheng, Jiang: 1 article (01/2014)|
06/01/2013 - "S and its alkene-oxidized metabolite styrene oxide (SO) were not lung toxic in CYP2F2(-/-) [knockout] mice, indicating S-induced mouse lung tumors are mediated through mouse-specific CYP2F2-generated ring-oxidized metabolite(s) in lung bronchioles. "
01/01/1994 - "Styrene oxide, like many intermediate metabolites of foodstuffs, is genotoxic and, if introduced directly into the stomachs of rodents in high doses/concentrations, gives rise to cancers of the forestomach. "
08/01/1993 - "The question addressed was whether stimulation of cell proliferation could be responsible for tumor induction in the forestomach by styrene 7,8-oxide (SO). "
08/01/1986 - "Rat and mouse forestomach tumors induced by chronic oral administration of styrene oxide."
05/01/2007 - "The aims of this study were to determine the blood dose after styrene exposure and to compare the genotoxic potency of styrene 7,8-oxide and gamma radiation in order to calculate the cancer risk by means of the rad-equivalence approach. "
|2.||Liver Neoplasms (Liver Cancer)
|3.||Chromosome Aberrations (Chromosome Abnormalities)
08/01/1979 - "Effects of styrene oxide on chromosome aberrations, sister chromatid exchange and hepatic drug biotransformation in chinese hamsters in vivo."
12/01/1994 - "Both styrene and its genotoxic metabolite, styrene oxide, can induce chromosome aberrations (CA) and sister chromatid exchanges (SCE) in vitro, but the chromosome-damaging ability of styrene is only manifested if test conditions favour its metabolic activation over inactivation. "
08/01/1979 - "In vivo inhalation exposure to styrene oxide (25, 50, 75 and 100 ppm) for 2, 4 or 20 days (25 ppm only) had no effects on chromosomal aberration rates or sister chromatid exchange (SCE) frequencies (BrdU/labelling performed in vitro) in the bone marrow cells of Chinese hamsters. "
01/01/1978 - "VII. Styrene and styrene oxide: II. Point mutations, chromosome aberrations and DNA repair induction analyses."
03/01/2005 - "Styrene can induce sister chromatid exchanges (SCE) and chromosome aberrations (CA) in vitro under test conditions that enhance metabolism of styrene to styrene 7,8-oxide (SO)or reduce detoxification of 50 by epoxide hydrolase. "
|4.||Body Weight (Weight, Body)
03/30/1995 - "The Hb-adduct levels found after styrene oxide treatment were compatible with a linear dose-response at low doses (< or = 0.4 mmol/kg body weight). "
08/01/1979 - "The only positive response in aberration frequency was obtained when styrene oxide was injected in lethal concentration (500 mg/kg body weight, i.p.) into the animal. "
01/01/2000 - "Mice were treated with single intraperitoneal doses of styrene (400 mg/kg of body weight), and with (R)-, (S)-, or racemic styrene oxide (150 mg/kg of body weight). "
03/01/1995 - "2. Both estroxide and estratetraenol induced microsomal epoxide hydrolase activity towards styrene oxide and estroxide itself 2-2.5-fold and glutathione conjugation of 1-chloro-2,4-dinitrobenzene (CDNB) 1.6-fold after intraperitoneal administration of a high dose of compound (300 mg per kg of body weight). "
02/01/1993 - "Synergistic neurotoxic effects of styrene oxide and acrylamide: glutathione-independent necrosis of cerebellar granule cells."
11/01/1983 - "The administration of 500 mumol of styrene oxide to perfused livers from diethyl maleate-treated rats caused periportal necrosis and extensive covalent binding of styrene oxide-derived radioactivity to tissue protein. "
|3.||Glutathione (Reduced Glutathione)
|5.||2-Acetylaminofluorene (2 Acetylaminofluorene)
|9.||Proteins (Proteins, Gene)