immune RNA (I-RNA)

01/25/2023 - "The Integrative Studies on the Functional A-to-I RNA Editing Events in Human Cancers."
01/01/2022 - "To facilitate more in-depth studies on the editing, this paper offers REIA (http://bioinfo-sysu.com/reia), an interactive web server that analyses and visualizes the association between human cancers and A-to-I RNA editing sites (RESs). "
01/01/2020 - "Recent studies have reported that aberrant A-to-I RNA editing profiles are implicated in cancers. "
03/01/1987 - "51Cr-labelled leucocyte adherence inhibition (LAI) assay was used as an index to study the activity of xenogenic immune RNA (iRNA) in inducing normal LACA mouse spleen lymphocytes to mediate tumor specific response in vitro. "
08/30/2023 - "Functional diffusion-weighted and dynamic contrast-enhanced MRI tumor measures were compared with tumor-infiltrating lymphocytes (TILs) and RNA immune signature scores. "

10/22/2019 - "A-to-I RNA editing in leukemia stem cells - set ADAR1 on the radar."
04/01/1985 - "[Method of obtaining immune RNA for use in the complex treatment of leukemia]."
01/01/1979 - "Sensitization in vitro to murine myeloblastic leukemia cells by xenogeneic immune RNA."
02/01/2001 - "The Cancer and Leukemia Group B is undertaking a prospective study using reverse transcriptase-polymerase chain reaction to detect MUC-I RNA in bone marrow and hilar and mediastinal lymph nodes removed at resection with the aim of distinguishing between stage I patients likely to remain disease-free for long periods and those at high risk of relapse. "
01/01/2023 - "Thus, we developed lentiviral ADAR1 and splicing reporters for non-invasive detection of splicing-mediated ADAR1 adenosine-to-inosine (A-to-I) RNA editing activation; a quantitative ADAR1p150 intracellular flow cytometric assay; a selective small-molecule inhibitor of splicing-mediated ADAR1 activation, Rebecsinib, which inhibits leukemia stem cell (LSC) self-renewal and prolongs humanized LSC mouse model survival at doses that spare normal hematopoietic stem and progenitor cells (HSPCs); and pre-IND studies showing favorable Rebecsinib toxicokinetic and pharmacodynamic (TK/PD) properties. "

01/01/1979 - "The effect of I-RNA therapy was studied in a B16 melanoma-C57BL/6J mouse system. "
05/01/1983 - "It appears that adjuvant immune RNA immunotherapy following surgical excision in the B16 melanoma model significantly improves survival and retards the spread of metastases."
05/01/1983 - "We have examined the efficacy of various combinations of surgery, xenogeneic immune RNA, xenogeneic normal RNA, tumor vaccine, and nonspecific splenocytes as adjuvant therapy for B16 melanoma in the C57BL/6J mouse system. "

06/13/2017 - "Although the anti-tumorigenic role of BLCAP has been examined in preliminarily studies, the relationship between BLCAP function and A-to-I RNA editing in cervical carcinogenesis still require further exploration. "
02/01/2014 - "In this study, we investigated the status and role of ADARs and altered A-to-I RNA editing in ESCC tumorigenesis. "
01/01/2022 - "Thus, A-to-I RNA editing events tend to play an essential role in CRC carcinogenesis."
06/01/2021 - "We profiled the landscape of the A-to-I RNA editome in these samples and interrogated whether the A-to-I processes participated in the gene expression regulation in oncogenesis. "
06/01/2021 - "Genome-wide expression changes mediated by A-to-I RNA editing correlate with hepatic oncogenesis."

01/01/2018 - "The current work is designed to study the effect of microorganism/fungi infection on the activity of A-to-I RNA editing in infected hosts. "
01/01/2023 - "Comparison of infected mosquitoes with their uninfected counterparts also revealed some unexpected immune RNA expression patterns earlier and later in the infection: significant differences in expression of several immune effectors were observed as early as 30 min after ingestion of the infected blood meal. "
01/01/2022 - "Innate immune RNA receptors mainly sense it during infection. "
01/01/2018 - "The increase of A-to-I RNA editing activities in infections with some influenza A viruses (H1N1 and H3N2) is linked to the up-regulation of ADAR1 but not ADAR2. "
01/01/2018 - "The infection of H1N1 and H3N2 significantly up-regulated normalized A-to-I RNA editing levels in human epithelial cells, whereas that of H5N1 did not change it and H7N9 infection significantly down-regulated normalized A-to-I editing level in A549 cells. "