|1.||Fu, Peter P: 11 articles (01/2014 - 01/2003)|
|2.||Chou, Ming W: 11 articles (05/2008 - 07/2002)|
|3.||Xia, Qingsu: 9 articles (01/2014 - 01/2003)|
|4.||Yan, Jian: 6 articles (01/2012 - 07/2002)|
|5.||Chen, Tao: 6 articles (01/2012 - 06/2004)|
|6.||Mei, Nan: 4 articles (01/2007 - 06/2004)|
|7.||Doerge, Daniel R: 4 articles (01/2006 - 07/2002)|
|8.||Chan, Po-Cheun: 3 articles (04/2004 - 01/2003)|
|9.||Lin, Ge: 2 articles (04/2009 - 05/2004)|
|10.||Guo, Lei: 2 articles (01/2007 - 01/2007)|
12/01/2015 - "The most common neoplastic process was hepatic hemangiosarcoma, which is consistent with published lifetime rodent riddelliine carcinogenesis studies. "
08/01/2004 - "In recent studies, riddelliine, a pyrrolizidine alkaloid, was found to increase rates of replication and apoptosis and induce hemangiosarcoma in the liver of rats and mice. "
05/01/2003 - "Under the conditions of these studies, there was clear evidence of carcinogenic activity of riddelliine in male and female F344/N rats based primarily on increased incidences of hemangiosarcoma in the liver. "
11/01/2002 - "In National Toxicology Program 2-year studies, riddelliine induced high incidences of hemangiosarcoma in the liver of F344/N rats (both sexes) and B6C3F1 mice (males). "
11/25/2004 - "Riddelliine is a naturally occurring pyrrolizidine alkaloid that induces liver hemangiosarcomas in rats and mice. "
12/01/2015 - "Exposure to riddelliine increased the odds of tumor development in a dose-responsive manner (odds ratio 2.05 and Wald 95% confidence limits between 1.2 and 3.4). "
09/01/2003 - "Riddelliine is a naturally occurring carcinogenic pyrrolizidine alkaloid that produces liver tumors in experimental animals. "
05/01/2003 - "Decreased incidences of hepatocellular neoplasms in male and female mice were related to riddelliine administration."
01/01/2003 - "These results strongly indicate the mechanistic data on liver tumor induction obtained for riddelliine in laboratory rodents is highly relevant to humans."
01/01/2003 - "Riddelliine, a widespread naturally occurring genotoxic pyrrolizidine alkaloid, induced liver tumors in rats and mice in an NTP 2-year carcinogenicity bioassay. "
|3.||Body Weight (Weight, Body)
01/01/2012 - "Groups of six rats were administered riddelliine at a mutagenic dose of 1 mg/kg body weight or with control vehicle 5 days a week for 12 weeks. "
01/01/2007 - "The female rats were gavaged with riddelliine at a dose of 1 mg/kg body weight 5 days a week for 12 weeks. "
01/01/2007 - "Groups of 6 Big Blue Fisher 344 rats were treated with riddelliine at 1 mg/kg body weight by gavage five times a week for 12 weeks or fed a diet containing 8% comfrey root for 12 weeks. "
11/25/2004 - "Female transgenic Big Blue rats were treated by gavage with 0.3 mg riddelliine per kg body weight, 5 days a week for 12 weeks. "
06/01/2004 - "To examine the mutagenicity of riddelliine, groups of six female transgenic Big Blue rats were gavaged with 0.1, 0.3, and 1.0 mg riddelliine per kg body weight. "
|4.||Phototoxic Dermatitis (Phototoxicity)
|10.||sodium phosphate (trisodium phosphate)