|1.||Zhu, Yi Zhun: 7 articles (05/2012 - 06/2009)|
|2.||Yuan, Feng-Lai: 3 articles (06/2015 - 12/2011)|
|3.||Li, Xia: 3 articles (06/2015 - 12/2011)|
|4.||Zhu, Yi-Zhun: 3 articles (01/2015 - 07/2009)|
|5.||Zhu, Yizhun: 3 articles (01/2014 - 09/2012)|
|6.||Guo, Wei: 3 articles (01/2013 - 09/2011)|
|7.||Gu, Xianfeng: 3 articles (01/2013 - 12/2010)|
|8.||Liu, Chunhua: 3 articles (01/2013 - 12/2010)|
|9.||Liu, Xin Hua: 3 articles (12/2010 - 06/2009)|
|10.||Xin, Hong: 3 articles (01/2010 - 06/2009)|
01/30/2013 - "We concluded that compound 2 played a cardioprotective role in hypoxia-induced primary cardiac myocytes apoptosis partly via modulating the PI3K/Akt pathway at a 10-fold lower concentration than leonurine."
12/01/2010 - "We recently reported that leonurine attenuated hypoxia-induced cardiomyocyte damage. "
12/01/2010 - "Pharmacological evaluation has shown that 1 possesses potent cardioprotective effect against hypoxia-induced neonatal rat ventricular myocytes damage at lower molar concentration (10-fold less than leonurine required and 100-fold less than SPRC required). "
11/01/2009 - "These results suggest that leonurine elicits potent cardioprotective effects in H9c2 cells, and these effects may be mediated by inhibition of intracellular Ca overload and apoptosis during hypoxia."
11/01/2009 - "Leonurine also reduced the cytosolic Ca overload induced by hypoxia. "
01/01/2010 - "The findings of this study suggest that leonurine has promising therapeutic effect for ischemic stroke treatment through antioxidant and anti-apoptotic mechanisms."
09/20/2012 - "Leonurine significantly alleviated neurological deficit, decreased brain water content and infarct volume after ischemic stroke, which was accompanied by decreased levels of MDA and Bax, increased activities of SOD, CAT, UCP4, and Bcl-2, and restored ultrastructure of mitochondria. "
11/01/2010 - "Leonurine has neuroprotective effects and carries a therapeutic potential of stroke prevention."
11/01/2010 - "Leonurine, 1 of the active compounds from purified Herba Leonuri, was studied to evaluate its possible therapeutic effects on ischemic stroke. "
01/01/2014 - "Leonurine, a major bioactive component from Herba Leonuri, shows therapeutic potential for cardiovascular disease and stroke prevention in some preclinical experiments. "
|3.||Myocardial Ischemia (Ischemic Heart Diseases)
01/01/2010 - "Leonurine, an alkaloid present in Herba Leonuri (HL), has shown biological effects such as antioxidant, anticoagulant, anti-apoptosis and protection against ischemic heart disease. "
12/15/2010 - "The results of present study demonstrated, for the first time that leonurine has potent anti-apoptotic effects after chronic myocardial ischemia mediated by activating the PI3K/Akt signaling pathway. "
12/15/2010 - "In the present study, we investigated the cardioprotective mechanism of leonurine the in vivo rat model of chronic myocardial ischemia and in vitro H9c2 cardiac myocyte model of oxidative stress. "
01/30/2013 - "Leonurine possesses cardioprotective effects in myocardial ischemia due to its anti-apoptotic properties. "
09/01/2011 - "Leonurine-cysteine analog conjugates as a new class of multifunctional anti-myocardial ischemia agent."
08/01/2010 - "Leonurine improves ischemia-induced myocardial injury through antioxidative activity."
01/01/2010 - "Neuroprotective effects of leonurine on ischemia/reperfusion-induced mitochondrial dysfunctions in rat cerebral cortex."
01/01/2010 - "We found that leonurine significantly improved neurological outcome and reduced ischemia/reperfusion (I/R)-induced cerebral infarction 24 h after MCAO. "
11/01/2009 - "In the present study, we examined the ability of a chemically synthesized compound based on the structure of leonurine, a phytochemical component of Herba leonuri, to protect H9c2 rat ventricular cells from apoptosis induced by hypoxia and serum deprivation, as a model of ischemia. "
08/01/2010 - "Moreover, the mRNA expression of the pro-apoptotic gene Bax was significantly down-regulated by 0.68-fold (p < 0.05) and the anti-apoptotic gene Bcl-2 was up-regulated by 1.41-fold (p < 0.05) in the leonurine treated groups as compared with acute myocardium ischemia (MI) controls measured by RT-PCR. "
04/01/2015 - "Leonurine ameliorates kidney fibrosis via suppressing TGF-β and NF-κB signaling pathway in UUO mice."
01/01/2013 - "In vivo studies using a post-MI model in rats indicated that administration of leonurine inhibited myocardial fibrosis while reducing cardiac Nox4 expression, ROS production, NF-κB activation, and plasma MMP-2 activity. "
01/01/2013 - "In conclusion, our results provide the first evidence that leonurine could prevent cardiac fibrosis and the activation of cardiac fibroblasts partly through modulation of a Nox4-ROS pathway."
|7.||Endothelin Receptors (Endothelin Receptor)