iturin A

from various strains of Bacillus subtilis; active component in bacillomycin B, R & eumycin; the lipid moiety is a mixture of amino long-chain saturated fatty acids & the peptide moiety consists of 7 amino acids; only iturin A has activity cyclic peptide; found in bacillomycin A, B, R & eumycin

Also Known As:

Networked: 14 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Bharti, Rashmi: 3 articles (12/2017 - 05/2015)
2.	Dey, Goutam: 3 articles (12/2017 - 05/2015)
3.	Mandal, Mahitosh: 3 articles (12/2017 - 05/2015)
4.	Sen, Ramkrishna: 3 articles (12/2017 - 05/2015)
5.	Huang, Qingsheng: 2 articles (05/2021 - 01/2019)
6.	Jiang, Chunmei: 2 articles (05/2021 - 01/2019)
7.	Shao, Dongyan: 2 articles (05/2021 - 01/2019)
8.	Shi, Junling: 2 articles (05/2021 - 01/2019)
9.	Sun, Hui: 2 articles (05/2021 - 01/2019)
10.	Zhao, Haobin: 2 articles (05/2021 - 01/2019)

Related Diseases

1.	Neoplasms (Cancer) 05/10/2021 - "In the tumor treated with iturin A, lymphocyte infiltration was found, and the expressions of TGF-β1and PD-L1 were decreased, which indicated that the tumor immune microenvironment was improved. " 05/10/2021 - "At a dosage of 3 mg/kg/day, iturin A significantly inhibited the further increase of the tumor weight by 58.55%, and reduced the expression of Ki67 in tumor. " 01/01/2017 - "Cancer invasion, migration and colony forming ability were significantly hampered by Iturin A. " 05/14/2015 - "In a xenograft model, Iturin A inhibited tumor growth with reduced expressions of Ki-67, CD-31, P-Akt, P-GSK3β, P-FoxO3a and P-MAPK. " 05/14/2015 - "Interestingly, overexpression of Akt with Akt plasmid in cancer cells caused highly susceptible to induce apoptosis by Iturin A treatment. "
2.	Adenocarcinoma 01/01/2019 - "This study revealed that iturin A-like lipopeptides produced by Bacillus subtillis induced both paraptosis and apoptosis in heterogeneous human epithelial colorectal adenocarcinoma (Caco-2) cells. "
3.	Hemolysis 12/01/1992 - "The presence of surfactin, at a concentration at which, alone, it is inactive, increases to a very large extent the haemolysis percent induced by iturin A. " 07/15/2005 - "Altogether these results indicate that iturin A-induced hemolysis follows a colloid-osmotic mechanism, with the formation of a membrane pore of average diameter 32 A. " 07/15/2005 - "The bacterial lipopeptide iturin A is able to cause hemolysis of human erythrocytes in a dose-dependent manner. " 04/25/1986 - "Binding experiments with radioactive antibiotics show that about 7 X 10(7) molecules of iturin A and 4 X 10(7) molecules of bacillomycin L are bound to one erythrocyte at the concentration giving 100% hemolysis. "
4.	Breast Neoplasms (Breast Cancer) 05/14/2015 - "Collectively, these findings imply that Iturin A has potential anticancer effect on breast cancer. " 05/14/2015 - "Proliferation of MDA-MB-231 and MCF-7 breast cancer cells were significantly inhibited by Iturin A and it induced apoptosis as confirmed by increased Sub G1 populations, DNA fragmentation, morphological changes and western blot analysis. " 12/11/2017 - "This mechanistic action might be the reason behind the chemo-sensitization effect of Iturin A in docetaxel resistant breast cancer cells. " 12/11/2017 - "Combination of Iturin A and docetaxel treatment significantly hampered the proliferation of docetaxel resistant MDA-MB-231 and MDA-MB-468 breast cancer cells. " 12/11/2017 - "Here, we have introduced 'Iturin A' as a potent chemosensitizer in docetaxel resistant breast cancer cells. "
5.	Persistent Vegetative State (Vegetative State) 10/01/2006 - "The induced spores became metabolically active vegetative state and produced lipopeptide antibiotic iturin A that added up the total production at the end of the fermentation. "

Related Drugs and Biologics

1.	Lipopeptides
2.	Anti-Bacterial Agents (Antibiotics)
3.	fengycin
4.	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)
5.	Secretory Immunoglobulin A (SIgA)
6.	Colloids (Colloid)
7.	Docetaxel (Taxotere)
8.	bacillomycin L

Related Therapies and Procedures

1.	Therapeutics