cholesteryl succinate

11/01/1998 - "We have studied the toxicity and therapeutic efficacy of amphotericin B in cholesterol hemisuccinate vesicles (ABCV) in the treatment of invasive aspergillosis in Balb/c mice. "
11/01/1998 - "Toxicity and therapeutic efficacy of amphotericin B delivered through cholesterol hemisuccinate vesicles in the treatment of experimental murine aspergillosis."
10/01/2000 - "Amphotericin B cholesterol hemisuccinate vesicles (ABCV) which reduces the toxicity of amphotericin B and thereby enhances its therapeutic efficacy in a murine model of aspergillosis was compared with conventional amphotericin B deoxycholate suspension (AmB(DOC)). "

04/01/2000 - "Delivery of liposome-encapsulated material (marker or oligonucleotides) into astrocytoma cells and primary astrocyte cultures was more effective with pH-sensitive liposomes [dioleoylphosphatidylethanolamine (DOPE)/cholesteryl hemisuccinate (CHEMS)] than with non-pH-sensitive liposomes (soy lecithin) or free material in solution. "

02/14/2000 - "Transfection of cultured cancer cells with the pH-sensitive liposomal vectors was found to be significantly more efficient than transfection with DOPE-cholesterol hemisuccinate-based vectors, the more commonly used pH-dependent, liposomal transfection formulation. "
09/01/1989 - "Series 3 (12 patients) was similar to series 2 except that the tumor cells were treated with cholesteryl hemisuccinate immediately before irradiation. "
05/01/1989 - "A monoclonal mouse antibody (MoHG) was produced using in vitro cultured AH66R tumor cells treated with cholesteryl hemisuccinate as an immunogen. "
01/01/1989 - "Tumor cell membranes enriched with cholesterol-hemisuccinate were able to increase anti-tumor immune response."
08/01/1986 - "Active immunotherapy of human solid tumor with autologous cells treated with cholesteryl hemisuccinate. "

09/01/1983 - "To further study this phenomenon, membrane microviscosity of ascites P-388 tumor cells was increased by adding cholesteryl hemisuccinate (CHS). "
11/01/1986 - "Evaluation of the efficiency of immunizations with syngeneic tumor vaccines prepared from cells treated with cholesterol hemisuccinate (CHS) was performed in five animal models: P815 mastocytoma in DBA/2 mice, MCA-103 fibrosarcoma in C57BL/6N mice, L1210 leukemia in DBA/2 mice, Ehrlich ascites carcinoma in C57BL/6N mice, and CBP pancreatic cancer in CB/SsLak hamsters. "

12/01/1996 - "Protection of acetaminophen-induced hepatocellular apoptosis and necrosis by cholesteryl hemisuccinate pretreatment."
12/01/1996 - "This study of acetaminophen (AAP) hepatotoxicity examined whether some aspects of the highly integrated process of drug-induced toxicity involves apoptosis, in addition to necrosis in vivo; and if so, whether cholesteryl hemisuccinate (CS) pretreatment would selectively interfere with apoptotic or necrotic liver cell death. "