4'- (9- acridinylamino)methanesulfonanilide

structure

Networked: 4 relevant articles (0 outcomes, 0 trials/studies)

1.	Neoplasms (Cancer) 10/01/1977 - "Tumor inhibition inhibition produced by isomeric, nitro-substituted 4'-(9-acridinylamino)methanesulfonanilide analogues of low base strength (pKa=4.79-5.72) might result from in vivo reduction to the corresponding, higher pKa (7.15-9.80), tumor active amines. " 02/01/1981 - "In an investigation of the structure-activity relationships in the 4'-(9-acridinylamino)methanesulfonanilide (AMSA) tumor inhibitory analogues, the DNA-binding properties of a series of simple 9-anilinoacridines were examined. " 04/01/1977 - "N1-Acyl derivatives of the tumor inhibitory 4'-(9-acridinylamino)methanesulfonanilide agents act as prodrugs undergoing deacylation to liberate the core agents on incubation with pH 7.5 buffer or mouse blood. "
2.	Leukemia L1210 03/01/1980 - "A series of substituted 4'-(9-acridinylamino)methanesulfonanilide (AMSA) derivatives have been tested for mutagenicity using Salmonella typhimurium strain TA 1537 and for antitumor activity against the L1210 leukemia in mice. "