indacrinone

polyvalent saluretic; RN given refers to parent cpd without isomeric designation; structure

Also Known As:

MK 196; MK 286; MK-286; indacrinic acid; indanone; indanone, (+-)-isomer; indanone, (R)-isomer; indanone, (S)-isomer; indanone, sodium salt; 6,7-dichloro-2-methyl-1-oxo-2-phenyl-5-indanyloxyacetic acid

Networked: 33 relevant articles (1 outcomes, 4 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Luqman, Suaib: 5 articles (11/2020 - 11/2007)
2.	Negi, Arvind S: 5 articles (11/2020 - 11/2007)
3.	Shanker, Karuna: 4 articles (11/2020 - 11/2007)
4.	Chanda, Debabrata: 3 articles (11/2020 - 12/2012)
5.	Fatima, Kaneez: 2 articles (11/2020 - 08/2015)
6.	Singh, Aastha: 2 articles (11/2020 - 08/2015)
7.	Singh, Arjun: 2 articles (11/2020 - 08/2015)
8.	Gan, Chang-Sheng: 2 articles (11/2016 - 07/2012)
9.	Nan, Dou-Dou: 2 articles (11/2016 - 07/2012)
10.	Qiao, Jin-Ping: 2 articles (11/2016 - 07/2012)

Related Diseases

1.	Adenocarcinoma 11/01/2020 - "The fluorinated benzylidene indanone 1, a new chemical entity (NCE) can further be optimized for better efficacy against breast adenocarcinoma.1."
2.	Alzheimer Disease (Alzheimer's Disease) 08/01/2023 - "The introduced indanone-aminopropoxy benzylidenes could be used in drug-discovery against Alzheimer's disease." 11/24/2014 - "A series of indanone derivatives were designed, synthesized, and tested using a variety of assays to assess their potential as anti-Alzheimer's disease (AD) agents. " 07/01/2012 - "A series of novel indanone derivatives was designed, synthesised and evaluated as potential agents for Alzheimer's disease. " 11/29/2016 - "A series of 6-methoxy indanone derivatives was synthesized and evaluated as potential probes for β-amyloid plaque imaging in Alzheimer's disease (AD). " 08/01/2023 - "Design, Synthesis, and Biological Evaluation of Novel Indanone Derivatives as Cholinesterase Inhibitors for Potential Use in Alzheimer's Disease."
3.	Cognitive Dysfunction 01/01/2018 - "Design, synthesis and pharmacological evaluation of some novel indanone derivatives as acetylcholinesterase inhibitors for the management of cognitive dysfunction." 01/01/2018 - "The present study reports the effect of indanone derivatives on scopolamine induced deficit cholinergic neurotransmission serving as promising leads for the therapeutics of cognitive dysfunction. "
4.	Colorectal Neoplasms (Colorectal Cancer) 01/01/2022 - "Anticancer effect of Indanone-based thiazolyl hydrazone derivative on p53 mutant colorectal cancer cell lines: An in vitro and in vivo study." 01/01/2022 - "It is noteworthy that one of the indanone-based thiazolyl hydrazone (ITH) derivatives, N-Indan-1-ylidene-N'-(4-Biphenyl-4-yl-thiazol-2-yl)-hydrazine (ITH-6), has a better cytotoxicity profile against p53 mutant colorectal cancer cells HT-29, COLO 205, and KM 12 than a p53 wild-type colorectal cancer cell line, such as HCT 116. "
5.	Nervous System Diseases (Neurological Disorders) 01/01/2023 - "The aim of the current work is to study the potential of some new indanone derivatives for the treatment of these neurological disorders. "

Related Drugs and Biologics

1.	Cholinesterase Inhibitors (Anticholinesterases)
2.	Hydrazones
3.	Cholinergic Agents (Cholinergics)
4.	Scopolamine (Hyoscine)
5.	Carbamates
6.	Diuretics
7.	Sodium Potassium Chloride Symporter Inhibitors (Loop Diuretics)
8.	Tubulin
9.	Ligands
10.	Hydrochlorothiazide (Esidrix)

Related Therapies and Procedures

1.	Therapeutics