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PI-IMP
Also Known As:
IMP-PI; periodate-oxidized 5'-inosinic acid
Networked:
2
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Heterocyclic Compounds: 198
Fused-Ring Heterocyclic Compounds
2-Ring Heterocyclic Compounds
Purines: 651
Purine Nucleotides: 140
Inosine Nucleotides: 2
Inosine Monophosphate: 1202
PI-IMP: 2
Nucleic Acids, Nucleotides, and Nucleosides: 1
Nucleotides: 15763
Ribonucleotides: 307
Inosine Nucleotides: 2
Inosine Monophosphate: 1202
PI-IMP: 2
Purine Nucleotides: 140
Inosine Nucleotides: 2
Inosine Monophosphate: 1202
PI-IMP: 2
Related Diseases
1.
Neoplasms (Cancer)
09/01/1976 - "
The ribonucleotide reductase activity in cell-free extracts prepared from Ehrlich tumor cells treated with Inox or PI-IMP in culture was decreased compared with the activity in the extracts from untreated cells.
"
09/01/1976 - "
Ribonucleotide reductase activity in cell-free extracts from Ehrlich tumor cells was inhibited by Inox and PI-IMP.
"
09/01/1976 - "
Incorporation of labeled cytidine into the RNA and DNA of Ehrlich tumor cells in culture was inhibited by both Inox and PI-IMP.
"
09/01/1976 - "
Periodate-oxidized inosine (Inox; NSC 118994) and periodate-oxidized 5'-inosinic acid (PI-IMP) were prepared and studied for their effects on ribonucleotide reductase activity in partially purified extracts from Ehrlich tumor cells and on nucleic acid synthesis in intact tumor cells in culture.
"
2.
Ischemia
12/01/1984 - "
Cerebral ischemia resulted in significantly increased levels of ADP, AMP + IMP, Pi, fructose 1,6-diphosphate, and glycerol 3-phosphate (global ischemia only), whereas ATP and phosphocreatine (PCr) levels declined significantly.
"
3.
Brain Ischemia (Cerebral Ischemia)
12/01/1984 - "
Cerebral ischemia resulted in significantly increased levels of ADP, AMP + IMP, Pi, fructose 1,6-diphosphate, and glycerol 3-phosphate (global ischemia only), whereas ATP and phosphocreatine (PCr) levels declined significantly.
"
Related Drugs and Biologics
1.
PI-IMP
2.
RNA (Ribonucleic Acid)
3.
Ribonucleotide Reductases (Ribonucleotide Reductase)
4.
Phosphocreatine (Neoton)
5.
Nucleic Acids
6.
Inosine
7.
DNA (Deoxyribonucleic Acid)
8.
Cytidine
9.
Adenosine Triphosphate (ATP)
10.
Adenosine Monophosphate (AMP)