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methylenecyclopropylacetic acid

metabolite of hypoglycin A; RN given refers to parent cpd

Also Known As:

MCPPA; methylenecyclopropaneacetic acid; methylenecyclopropylacetic acid, sodium salt

Networked: 5 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Alicyclic Hydrocarbons: 1
      - Cycloparaffins: 6
        Cyclopropanes: 9
        methylenecyclopropylacetic acid: 5

Experts

1.	González-Medina, Sonia: 1 article (05/2021)
2.	Hyde, Carolyne: 1 article (05/2021)
3.	Lovera, Imogen: 1 article (05/2021)
4.	Piercy, Richard J: 1 article (05/2021)

Related Diseases

1.	Inborn Genetic Diseases (Disease, Hereditary) 03/01/1997 - "To examine the changes in coenzyme A profile and the possible corrective effects of carnitine supplementation in the genetic disorders of mitochondrial beta-oxidation, we carried out experiments using an inhibitor of multiple acyl-CoA dehydrogenase enzymes, methylenecyclopropaneacetic acid (MCPA), in rat hepatocytes. "
2.	Rhabdomyolysis 05/01/2021 - "Measurement of hypoglycin A (HGA) and its toxic metabolite, methylenecyclopropylacetic acid (MCPA), in equine serum confirms a diagnosis of atypical myopathy (AM), a pasture-associated toxic rhabdomyolysis with high mortality linked to the ingestion of Acer trees plant material. "
3.	Poisoning 03/01/1988 - "There are molecular structural similarities between 4-en-valproate and 2 known hepatotoxins (4-en-pentanoate and methylenecyclopropylacetic acid, the latter being responsible for hypoglycin poisoning). "
4.	Muscular Diseases (Myopathy) 05/01/2021 - "Measurement of hypoglycin A (HGA) and its toxic metabolite, methylenecyclopropylacetic acid (MCPA), in equine serum confirms a diagnosis of atypical myopathy (AM), a pasture-associated toxic rhabdomyolysis with high mortality linked to the ingestion of Acer trees plant material. "
5.	isovaleric Acidemia 07/01/1976 - "A pattern of inhibition of leucine oxidation similar to that seen in isovaleric acidemia cells was induced in normal cells by the addition of 0.7 mM methylenecyclopropylacetic acid to the assay medium. "

Related Drugs and Biologics

1.	hypoglycin
2.	2-Methyl-4-chlorophenoxyacetic Acid (MCPA)
3.	Acyl-CoA Dehydrogenase (Medium-Chain Acyl-Coenzyme A Dehydrogenase)
4.	Valerates
5.	Leucine (L-Leucine)
6.	Enzymes
7.	Coenzyme A (CoA)
8.	Carnitine (L-Carnitine)