HOME
PRODUCTS
COMPANY
CONTACT
FAQ
Research
Dictionary
Pharma
Sign Up
FREE
or
Login
Username:
Password:
Remember login
Login
Send password reminder...
4-methyl-5-amino-1-formylisoquinoline thiosemicarbazone
structure
Also Known As:
4-methyl-5-aminoisoquinoline thiosemicarbazone; MAIQ; MAIQ 1; MAIQ-1
Networked:
7
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Heterocyclic Compounds: 198
Fused-Ring Heterocyclic Compounds
2-Ring Heterocyclic Compounds
Isoquinolines: 34
4-methyl-5-amino-1-formylisoquinoline thiosemicarbazone: 7
Experts
1.
Cory, Joseph G
: 1 article (01/2002)
2.
Crenshaw, Taria R
: 1 article (01/2002)
Related Diseases
1.
Leukemia L1210
09/01/1997 - "
Altered efflux properties of mouse leukemia L1210 cells resistant to 4-methyl-5-amino-1-formylisoquinoline thiosemicarbazone.
"
01/01/1996 - "
Characterization of mouse leukemia L1210 cells resistant to the ribonucleotide reductase inhibitor 4-methyl-5-amino-1-formylisoquinoline thiosemicarbazone.
"
09/01/1999 - "
Mouse leukemia L1210 cells selected for resistance to the ribonucleotide reductase inhibitor, 4-methyl-5-amino-1-formylisoquinoline thiosemicarbazone show altered response to DNA damaging agents.
"
01/01/2002 - "
Overexpression of protein disulfide isomerase-like protein in a mouse leukemia L1210 cell line selected for resistance to 4-methyl-5-amino-1-formylisoquinoline thiosemicarbazone, a ribonucleotide reductase inhibitor.
"
09/01/1997 - "
A mouse leukemia L1210 cell line, denoted MQ-580, that was selected for resistance to the ribonucleotide reductase inhibitor, 4-methyl-5-amino-1-formylisoquinoline thiosemicarbazone (MAIQ), in addition to having altered properties at the ribonucleotide reductase site had other alterations that contributed to its resistant phenotype; these included the expression of p-glycoprotein and the multi-drug resistance associated protein (MRP).
"
2.
Neoplasms (Cancer)
11/15/1988 - "
Microsomes prepared from Ehrlich tumor cells were ineffective as inactivators of MAIQ.
"
11/01/1980 - "
Effects of the ferrous chelate of 4-methyl-5-amino-1-formylisoquinoline thiosemicarbazone (MAIQ-1) on the kinetics of reduction of CDP by ribonucleotide reductase of the Novikoff tumor.
"
3.
Hypersensitivity (Allergy)
07/01/1989 - "
A transplason mutagenized strain with marked structural modifications in RNR2 DNA and mRNA showed an extreme hypersensitivity to hydroxyurea but not to MAIQ, providing evidence that the two drugs do not inhibit the RNR2 subunit by the same mechanism.
"
Related Drugs and Biologics
1.
Ribonucleotide Reductases (Ribonucleotide Reductase)
2.
4-methyl-5-amino-1-formylisoquinoline thiosemicarbazone
3.
Proteins (Proteins, Gene)
4.
DNA (Deoxyribonucleic Acid)
5.
Member 1 Subfamily B ATP Binding Cassette Transporter
6.
Protein Disulfide-Isomerases
7.
Messenger RNA (mRNA)
8.
Iron
9.
Hydroxyurea (Hydrea)
10.
Enzymes