|1.||Figueiredo, Carlos R: 1 article (01/2012)|
|2.||Romoff, Paulete: 1 article (01/2012)|
|3.||Lago, João H G: 1 article (01/2012)|
|4.||Favero, Oriana A: 1 article (01/2012)|
|5.||Farias, Camyla F: 1 article (01/2012)|
|6.||Arruda, Denise C: 1 article (01/2012)|
|7.||Ferreira, Marcelo J P: 1 article (01/2012)|
|8.||Girola, Natália: 1 article (01/2012)|
|9.||Matsuo, Alisson L: 1 article (01/2012)|
|10.||Massaoka, Mariana H: 1 article (01/2012)|
01/01/2012 - "The jacaranone antitumor activity was shown against several human cancer cell lines in vitro. "
01/12/2009 - "Jacaranone, the most important constituent isolated is known to possess anti-cancer activity. "
01/01/2012 - "Jacaranone renders antiproliferative and proapoptotic responses in tumor cells, by acting on Akt and p38 MAPK signaling pathways through generation of reactive oxygen species (ROS). "
|3.||Melanoma (Melanoma, Malignant)
01/01/2012 - "Notably, treatment of melanoma growing subcutaneously in mice with jacaranone significantly extended the mean survival times in a dose-dependent manner. "
01/01/2012 - "Moreover, the induction of apoptosis in murine melanoma cells and jacaranone antitumor activity in vivo, in a melanoma experimental model, were also shown. "
01/01/2012 - "The results provide evidence for the mechanisms of action of jacaranone and emphasize the potential use of this quinone for the treatment of melanoma."
01/01/2012 - "Recently, we isolated jacaranone from Pentacalia desiderabilis, a benzoquinone derivative that showed a broad antitumor activity and protective anti-melanoma effect in a syngeneic model. "
01/01/2012 - "Jacaranone induces apoptosis in melanoma cells via ROS-mediated downregulation of Akt and p38 MAPK activation and displays antitumor activity in vivo."
|1.||p38 Mitogen-Activated Protein Kinases
|2.||Reactive Oxygen Species (Oxygen Radicals)