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hydroxyhydroquinone (hydroxyquinol)

Also Known As:

hydroxyquinol; 1,2,4-benzenetriol; 1,2,4-trihydroxybenzene

Networked: 12 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Benzene Derivatives: 17
        Phenols: 677
        Hydroquinones: 47
        hydroxyhydroquinone: 12

Experts

1.	Fujii, Akihiko: 2 articles (01/2008 - 04/2006)
2.	Saito, Ikuo: 2 articles (01/2008 - 04/2006)
3.	Suzuki, Atsushi: 2 articles (01/2008 - 04/2006)
4.	Tokimitsu, Ichiro: 2 articles (01/2008 - 04/2006)
5.	Devidas Bhatia, Dhiraj: 1 article (09/2020)
6.	Sathisaran, Indumathi: 1 article (09/2020)
7.	Vishvanath Dalvi, Sameer: 1 article (09/2020)
8.	Aibara, Yoshiki: 1 article (04/2019)
9.	Chayama, Kazuaki: 1 article (04/2019)
10.	Goto, Chikara: 1 article (04/2019)

Related Diseases

1.	Aneuploidy (Aneuploid) 03/01/1994 - "Detection of 1,2,4-benzenetriol induced aneuploidy and microtubule disruption by fluorescence in situ hybridization and immunocytochemistry." 03/01/1994 - "Here, we report its use in human HL60 cells to detect aneuploidy induced by the benzene metabolite, 1,2,4-benzenetriol (BT). " 12/01/1996 - "In previous studies, FISH has been used to demonstrate that the benzene metabolites hydroquinone and 1,2,4-benzenetriol induce aneuploidy of chromosomes 7 and 9 in cultures of human cells. "
2.	Chromosome Aberrations (Chromosome Abnormalities) 02/10/2009 - "In the present study, in vitro genotoxicity of benzene (BZ) and its major metabolites [p-benzoquinone (BQ), hydroquinone (HQ), catechol (CT), 1,2,4-benzenetriol (BT) and trans-trans muconic acid (MA)] at concentrations 0.5-50 microM, was assessed in Chinese hamster ovary (CHO) cells employing the alkaline Comet assay, cytokinesis blocked micronucleus (CBMN) assay, flow cytometric analysis of micronucleus (flow MN) and chromosome aberration (CA) test. "
3.	Hypertension (High Blood Pressure) 04/17/2006 - "Improvement of hypertension and vascular dysfunction by hydroxyhydroquinone-free coffee in a genetic model of hypertension." 04/01/2019 - "Coffee with a high content of chlorogenic acids and low content of hydroxyhydroquinone improves postprandial endothelial dysfunction in patients with borderline and stage 1 hypertension." 01/01/2008 - "The interaction between hydroxyhydroquinone (HHQ) and 5-caffeoylquinic acid (CQA) was examined, in an attempt to understand the controversial effects of coffee on hypertension. "
4.	Neoplasms (Cancer) 09/25/2020 - "Cell invasion assay conducted on 3D tumor spheroid models showed that Curcumin-Hydroxyquinol (CUR-HXQ) cocrystal completely inhibited cell invasion whereas CUR-FAD (1:1) coamorphous solid induced enhanced invasion of cells from spheroid models." 04/01/2011 - "The health-promoting properties of coffee are often attributed to its rich phytochemistry, including caffeine, chlorogenic acid, caffeic acid, hydroxyhydroquinone (HHQ), etc. Many research investigations, epidemiological studies, and meta-analyses regarding coffee consumption revealed its inverse correlation with that of diabetes mellitus, various cancer lines, Parkinsonism, and Alzheimer's disease. "
5.	Leukemia 08/01/1992 - "Using P1 nuclease enhanced 32P postlabeling, we investigated DNA adduct formation in HL-60 promyelocytic leukemia cells treated with the benzene metabolites hydroquinone, catechol, and 1,2,4-benzenetriol. " 01/01/1991 - "Recently, we have found that exposure of human promyelocytic leukemia (HL-60) cells (a cell line rich in myeloperoxidase), to the benzene metabolites, hydroquinone and 1,2,4-benzenetriol results in increased steady-state levels of 8-hydroxydeoxyguanosine a marker of oxidative DNA damage. "

Related Drugs and Biologics

1.	Benzene (Benzole)
2.	hydroquinone (Esoterica)
3.	catechol (pyrocatechol)
4.	muconic acid (cis,cis-muconate)
5.	quinone (benzoquinone)
6.	Coffee
7.	Acids
8.	DNA Adducts
9.	Peroxidase (Myeloperoxidase)
10.	Glucose (Dextrose)