hydrastine

Also Known As:

beta-hydrastine; hydrastine hydrochloride, (S-(R*,S*))-isomer; hydrastine, (R-(R*,R*))-isomer; hydrastine, (R-(R*,S*))-isomer; isocoryne; 6,7-dimethoxy-3-(5,6,7,8-tetrahydro-6-methyl-1,3-dioxolo(4,5-g)isoquinoline-5-yl)-1(3H)-isobenzo furan

Networked: 3 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Alkaloids: 5398
  - Benzylisoquinolines: 151
    - hydrastine: 3
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Isoquinolines: 34
      - Benzylisoquinolines: 151
        hydrastine: 3

Experts

1.	Chen, Meng: 1 article (04/2016)
2.	Cheng, Maosheng: 1 article (04/2016)
3.	Guo, Bingyu: 1 article (04/2016)
4.	Li, Feng: 1 article (04/2016)
5.	Li, Xiaodong: 1 article (04/2016)
6.	Song, Shuai: 1 article (04/2016)
7.	Zhao, Dongmei: 1 article (04/2016)

Related Diseases

1.	Adenocarcinoma of Lung 04/01/2016 - "All of these data indicate that (-)-β-hydrastine, as a novel PAK4 inhibitor, suppresses the proliferation and invasion of lung adenocarcinoma cells. " 04/01/2016 - "In addition, (-)-β-hydrastine significantly suppressed the migration and invasion of human lung adenocarcinoma cells in conjunction with concomitant blockage of the PAK4/LIMK1/cofilin, PAK4/SCG10 and PAK4/MMP2 pathways. " 04/01/2016 - "Moreover, inhibition of PAK4 kinase activity by (-)-β-hydrastine also promoted the early apoptosis of lung adenocarcinoma cells through the mitochondrial apoptosis pathway. " 04/01/2016 - "(-)-β-hydrastine suppresses the proliferation and invasion of human lung adenocarcinoma cells by inhibiting PAK4 kinase activity." 04/01/2016 - "In the present study, (-)-β-hydrastine suppressed lung adenocarcinoma cell proliferation by inhibiting expression of cyclin D1/D3 and CDK2/4/6, leading to cell cycle arrest at the G1 phase, in a PAK4 kinase-dependent manner. "
2.	Neoplasms (Cancer) 04/01/2016 - "However, whether (-)-β-hydrastine affects the tumor signaling pathway remains unexplored. "
3.	Echinococcosis (Hydatid Cysts) 03/01/1989 - "It seems that d-hydrastine has a profound intracellular effect on experimental Echinococcus granulosus cysts in mice, and that it may be a promising drug for treating hydatidosis."
4.	Cysts 03/01/1989 - "Cysts from d-hydrastine treated mice were shown by transmission electron microscope to have dissolution of the microtriches, disturbance of organelles in their arrangement, dilatation and disruption of microtubules, increase in size and number of lysosomes, a decrease in number of Golgi complexes and lessening in density and swelling of mitochondria. " 03/01/1989 - "The ultrastructural changes in the germinal membranes of Echinococcus granulosus cysts treated with d-hydrastine (3.75 mg/(kg.d), ig) for 20 d were studied. " 03/01/1989 - "[Effect of d-hydrastine on the ultrastructure of experimental Echinococcus granulosus cyst in mice]." 03/01/1989 - "It seems that d-hydrastine has a profound intracellular effect on experimental Echinococcus granulosus cysts in mice, and that it may be a promising drug for treating hydatidosis."
5.	Congenital Abnormalities (Deformity) 01/01/1991 - "Disruption of external plasma membrane, hook detachment, sucker deformity of protoscolices exposed to hydrastine were demonstrated by scanning electron microscopy. "

Related Drugs and Biologics

1.	Cyclin D1
2.	Phosphotransferases (Kinase)
3.	Actin Depolymerizing Factors (Cofilins)