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hexamethylenebis(dimethyl- (3- phthalimidopropyl)ammonium bromide) (W 84)

antidote in organophosphate poisoning

Also Known As:

W 84; HDMPPA; W-84; 1,6-Hexanediaminium, N,N'-bis(3-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)propyl)-N,N,N',N'-tetramethyl-, dibromide

Networked: 4 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Carboxylic Acids: 973
  - Carbocyclic Acids
    - Phthalic Acids: 1
      - Phthalimides: 12
        hexamethylenebis(dimethyl-(3-phthalimidopropyl)ammonium bromide): 4
- Imides: 79
  - Phthalimides: 12
    - hexamethylenebis(dimethyl-(3-phthalimidopropyl)ammonium bromide): 4
Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Isoindoles: 18
      - Phthalimides: 12
        hexamethylenebis(dimethyl-(3-phthalimidopropyl)ammonium bromide): 4

Experts

1.	Song, Yeong Ok: 3 articles (05/2018 - 12/2007)
2.	Noh, Jeong Sook: 2 articles (05/2018 - 12/2009)
3.	Kim, Hyun Ju: 2 articles (12/2009 - 12/2007)
4.	Cho, Eun Ju: 1 article (05/2018)
5.	Woo, Minji: 1 article (05/2018)
6.	Kwon, Myung Ja: 1 article (12/2009)
7.	Apostol, P: 1 article (09/2009)
8.	Belusică, L: 1 article (09/2009)
9.	Cimponeriu, D: 1 article (09/2009)
10.	Cojocaru, M: 1 article (09/2009)

Related Diseases

1.	Atherosclerosis 12/12/2007 - "These findings suggest that HDMPPA prevents the development of aortic atherosclerosis in high-cholesterol-fed rabbits. " 12/12/2007 - "The effects of 3-(4'-hydroxyl-3',5'-dimethoxyphenyl)propionic acid (HDMPPA) originating from Korean cabbage kimchi were investigated, showing an antioxidant effect on the prevention of atherosclerosis in hypercholesterolemic rabbits. " 12/01/2009 - "In conclusion, HDMPPA in kimchi may attenuate atherosclerosis in apoE KO mice through retardation of ROS generation via down-regulating the mRNA expression of p47phox and rac-1, which are the components of NADPH oxidase." 12/01/2009 - "We examined the beneficial effects of an active principle in kimchi, 3-(4'-hydroxyl-3',5'-dimethoxyphenyl)propionic acid (HDMPPA), on atherogenesis in apolipoprotein E knockout (apoE KO) mice. "
2.	Colorectal Neoplasms (Colorectal Cancer) 09/01/2009 - "Blood samples were obtained, after informed consent, from individuals with colorectal cancer (n=108, M:W = 64:44), and healthy persons (n=150, M:W = 84:66). "
3.	Body Weight (Weight, Body) 05/16/2018 - "Mice were subjected to oral administration of 10 mg of capsaicin, 50 mg of 3-(4'-hydroxyl-3',5'-dimethoxyphenyl)propionic acid (HDMPPA), 50 mg of quercetin, 50 mg of ascorbic acid, or 200 mg of kimchi methanol extract (KME) per kilogram of body weight for 2 weeks ( n = 7 per group). "

Related Drugs and Biologics

1.	3- (4'- hydroxyl- 3',5'- dimethoxyphenyl)propionic acid
2.	NADPH Oxidases (NAD(P)H oxidase)
3.	Messenger RNA (mRNA)
4.	Quercetin
5.	Cholesterol
6.	Capsaicin (Zostrix)
7.	Ascorbic Acid (Vitamin C)
8.	Apolipoproteins E (ApoE)
9.	Apolipoproteins
10.	Antioxidants

Related Therapies and Procedures

1.	Oral Administration