hesperetin

10/01/2018 - "Hesperetin and nano-hesperetin treatment improved the behavioral disorder and reduced the oxidative stress in brain and significantly (p <  0.05) plasma's inflammation indexes. "
03/18/2023 - "Our findings suggest that hesperetin ameliorates LPS-induced renal structural and functional injury through suppressing oxidative stress, apoptosis, and inflammation."
10/01/2023 - "These results substantiate that hesperetin activates autophagy and inhibits apoptosis and inflammation. "
09/01/2022 - "7-O-(2- (Propylamino)-2-oxoethyl) hesperetin attenuates inflammation and protects against alcoholic liver injury by NLRP12."
01/01/2022 - "O-alkyl and o-benzyl hesperetin derivative-1L attenuates inflammation and protects against alcoholic liver injury via inhibition of BRD2-NF-κB signaling pathway."

06/01/2012 - "AIM OF THE SCOPE: In the present study, we have evaluated the chemopreventive efficacy of hesperetin against rat colon carcinogenesis in male Wistar rats. "
06/01/2012 - "Chemopreventive efficacy of hesperetin (citrus flavonone) against 1,2-dimethylhydrazine-induced rat colon carcinogenesis."
12/05/2015 - "The present study was designed to investigate the mechanism-based chemopreventive nature of hesperetin (HSP) against B[a]P induced lung carcinogenesis in Swiss albino mice. "
11/01/2021 - "However, the effects of hesperetin on KSHV replication and KSHV-induced tumorigenesis have not yet been reported. "
12/01/2020 - "Modulating effect of hesperetin on the molecular expression pattern of apoptotic and cell proliferative markers in 7,12-dimethylbenz(a)anthracene-induced oral carcinogenesis."

12/01/2019 - "Together, these results indicated that the anti-inflammatory effect of hesperetin is associated with the TLR4-MyD88-NF-κB pathway, and that hesperetin shows therapeutic potential for LPS-induced acute lung injury."
12/15/2015 - "Rats were then randomly divided into six groups: the lung protective ventilation group (n=20, LV group), injurious ventilation group (n=20, HV group), vehicle-treated injurious ventilation group (n=20, LV+vehicle group), hesperetin (10mg/kg)-treated acute lung injury group (n=20, HV+Hsp (10mg)), hesperetin (20mg/kg)-treated acute lung injury group (n=20, HV+Hsp (20mg)), and hesperetin (40mg/kg)-treated acute lung injury group (n=20, HV+Hsp (40mg)). "
12/15/2015 - "These results suggest that hesperetin may be a potential novel therapeutic candidate for protection against ventilator-induced acute lung injury. "
12/15/2015 - "In present study, we investigated the protective effect of hesperetin on ventilator-induced acute lung injury in rats. "
12/15/2015 - "Rats were orally administered hesperetin (10, 20, or 40mg/kg) two hour before acute lung injury was induced by mechanical ventilation. "

09/11/2023 - "Hesperetin attenuates the expression of markers of adipose tissue fibrosis in pre-adipocytes."
10/01/2022 - "Hesperetin derivative decreases CCl4 -induced hepatic fibrosis by Ptch1-dependent mechanisms."
10/01/2017 - "Hesperetin alleviates renal interstitial fibrosis by inhibiting tubular epithelial-mesenchymal transition in vivo and in vitro."
09/01/2017 - "However, it has remained elusive whether and how hesperetin has a role in cardiac fibrosis post-MI. "
05/11/2021 - "In a rat model of high-fat diet (HFD)-induced NAFLD, we confirmed that hesperetin relieved hepatic steatosis, oxidative stress, inflammatory cell infiltration and fibrosis. "

09/01/2023 - "In this study, we examined the effect of varying doses and exposure times of hesperetin on MCF-7 and MDA-MB-231 cancer cells, as well as MCF-10A normal cells. "
02/16/2022 - "Controlled supramolecular interaction to enhance the bioavailability of hesperetin to targeted cancer cells through graphyne: a comprehensive in silico study."
02/13/2023 - "We suggest that hesperetin can protect cancer cells during the transient period and may extend survival. "
12/01/2022 - "Hesperetin also decreased the level of heat shock protein 70 (Hsp70), a negative regulator of the mitochondrial apoptosis pathway, often overexpressed in various cancer cells and suspected to contribute to tumor development. "
10/01/2022 - "Hesperetin as an anti-SARS-CoV-2 agent can inhibit COVID-19-associated cancer progression by suppressing intracellular signaling pathways."