galactomannan

a galectin inhibitor

Also Known As:

D-galacto-D-mannan, phosphate; GM-CT-01; beta-D-mannopyranosyl-(1->4) with alpha-D-galactopyranosyl branch through (1->6) linkage; davanat; galactomannan C; galactomannan Type I; galactomannan Type II; galactomannan, phosphate; peptidophosphogalactomannan; phosphogalactomannan

Networked: 918 relevant articles (56 outcomes, 102 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Carbohydrates: 22023
- Polysaccharides: 15383
  - Mannans: 580
    - galactomannan: 918
- Sugars: 11126
  - Monosaccharides: 889
    - Hexoses: 549
      - Galactose: 3212
        galactomannan: 918

Experts

1.	Walsh, Thomas J: 21 articles (01/2021 - 01/2002)
2.	Maertens, Johan: 20 articles (01/2022 - 11/2002)
3.	Hoenigl, Martin: 16 articles (07/2022 - 04/2012)
4.	Lagrou, Katrien: 14 articles (05/2022 - 09/2004)
5.	Petraitiene, Ruta: 13 articles (01/2021 - 01/2002)
6.	Verweij, Paul E: 11 articles (12/2021 - 01/2004)
7.	Wheat, L Joseph: 11 articles (12/2021 - 06/2007)
8.	Petraitis, Vidmantas: 11 articles (01/2021 - 01/2002)
9.	Viscoli, Claudio: 10 articles (11/2019 - 04/2002)
10.	Prattes, Juergen: 9 articles (01/2022 - 10/2014)

Related Diseases

1.	Aspergillosis 01/01/2018 - "In recent years, galactomannan detection has markedly improved the diagnosis of invasive aspergillosis, but very little is known on how physicians deal with this test in clinical practice. " 09/01/2017 - "Our study shows that PTX3 measurements in BAL samples were significantly higher among patients with invasive aspergillosis and may help to identify patients with Aspergillus colonization and false-positive galactomannan in BAL samples." 12/01/2013 - "Screening with serum galactomannan might be associated with better outcome than symptom-triggered galactomannan testing in allogeneic HSCT recipients with invasive aspergillosis." 01/01/2015 - "The Platelia Aspergillus Ag assay (Bio-Rad) is designed for detecting Aspergillus galactomannan (GM) and is widely used for diagnosing invasive aspergillosis but is hampered by variable occurrences of unreproducible positive results. " 02/01/2014 - "Nowadays, the galactomannan (GM) assay has been widely used as an indication of invasive aspergillosis, even though the test is known to generate false-positive results. "
2.	Invasive Pulmonary Aspergillosis 04/01/2000 - "It was concluded that, in this model, quantitative galactomannan detection is superior to PCR in diagnosing and monitoring invasive pulmonary aspergillosis." 04/01/2000 - "Quantitative galactomannan detection is superior to PCR in diagnosing and monitoring invasive pulmonary aspergillosis in an experimental rat model." 01/01/2018 - "The present study investigated the improvement in the diagnosis of invasive pulmonary aspergillosis (IPA) adding a molecular test on bronchoalveolar lavage (BAL) to the routine diagnostic approach including microscopy, culture and galactomannan (GM) immunoassay. " 01/24/2023 - "Here, we present the long-term kinetics of serum galactomannan in two severely immunocompromised adolescents with invasive pulmonary aspergillosis (IPA) who were cured after complicated clinical courses. " 06/01/2014 - "Galactomannan detection in bronchoalveolar lavage (BAL) fluid samples (GM test) is currently considered the gold standard test for diagnosing invasive pulmonary aspergillosis (IPA). "
3.	Invasive Fungal Infections 06/01/2004 - "This suggests that the PCR and galactomannan assays, previously suggested as useful in the management of invasive fungal infections in neutropenic haematological patients, may be suitable for application to a broad range of clinical situations and sample types." 01/01/2022 - "Definitions have been proposed for possible/probable/proven CAPA, but distinction between colonization and invasive fungal infection is difficult and not possible in most cases in the absence of histopathological proof or positive galactomannan in serum. " 07/01/2017 - "Galactomannan (GM) assay is commonly used as an early diagnostic tool for invasive fungal infection (IFI) in high-risk hematology patients. " 04/01/2017 - "Diagnostic Values and Limitations of (1,3)-β-D-Glucans and Galactomannan Assays for Invasive Fungal Infection in Patients Admitted to Pediatric Intensive Care Unit." 05/01/2008 - "Quick and reliable galactomannan detection in crude minced lung specimens from haematological patients with suspected invasive fungal infection: results from a case series."
4.	Infections 01/25/2012 - "In this study, we investigated if a recently developed β-galactomannan (βGM) had a similar protective role compared to Saccharomyces cerevisiae var. Boulardii (Scb), a proven probiotic, in the context of enterotoxigenic Escherichia coli (ETEC) infection. " 01/01/2022 - "Primary endpoints assessed were survival, cerebral fungal burden, galactomannan index, and drug concentrations in brain homogenate at 2, 3, 5, and 11 days after infection. " 01/01/2022 - "However, our findings emphasize once more the importance of considering the possibility of dual mould infections, even in patients with a positive galactomannan detection." 06/15/2021 - "Histopathologic examination led to the diagnosis of infection in 57% of the patients followed by culture (23.7%), galactomannan assay (8.5%), and molecular method (3.3%). " 01/01/2021 - "Challenges with Utilizing the 1,3-Beta-d-Glucan and Galactomannan Assays To Diagnose Invasive Mold Infections in Immunocompromised Children."
5.	Neoplasms (Cancer) 09/30/2023 - "The recently revised consensus definitions from the European Organization for Research and Treatment of Cancer and the Mycosis Study Group have adjusted the threshold for positive galactomannan testing based on the sample type, and have excluded 1,3-β-D-glucan testing as a mycological criterion. " 07/01/2015 - "Adult patients who met the modified criteria for proven and probable PM (over an 11-year period) and IPA (over a 6-year period, owing to the availability of the galactomannan assay) according to the modified European Organization for Research and Treatment of Cancer/Mycosis Study Group definitions were retrospectively enrolled. " 11/01/2011 - "Previous studies reported that serum galactomannan (GM) levels correlate strongly with IA outcomes in patients with haematological cancers. " 05/15/2006 - "Studies of the galactomannan assay that used the European Organization for Research and Treatment of Cancer or similar criteria as a reference standard and provided data to calculate sensitivity and specificity were included. " 08/27/2021 - "Late mortality was associated with relapsed/refractory malignancy and elevated serum galactomannan. "

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Related Therapies and Procedures

1.	Therapeutics
2.	Drug Therapy (Chemotherapy)
3.	Immunotherapy
4.	Liver Transplantation
5.	Enteral Nutrition (Feeding, Tube)