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fluorophosphate (sodium monofluorophosphate)

inhibits Phosphorylas phosphatase irreversibly; RN given refers to parent cpd
Also Known As:
sodium monofluorophosphate; Mono-Tridin; Na-MFP; ammonium monofluorophosphate; calcium fluorophosphate; calcium monofluorophosphate; fluorophosphate hydrate, calcium salt; fluorophosphate, barium salt; fluorophosphate, calcium salt; fluorophosphate, diammonium salt; fluorophosphate, disodium salt; fluorophosphate, monoammonium salt; fluorophosphate, potassium salt; fluorophosphate, sodium salt; fluorophosphate, tin salt; fluorophosphate, vanadium salt; monofluorophosphate
Networked: 180 relevant articles (31 outcomes, 34 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1. Zhang, Y P: 7 articles (01/2015 - 01/2009)
2. DeVizio, W: 7 articles (01/2012 - 06/2000)
3. Mateo, L R: 6 articles (01/2015 - 01/2009)
4. Mateo, Luis R: 5 articles (09/2015 - 01/2009)
5. Cummins, D: 5 articles (08/2013 - 01/2009)
6. DeVizio, William: 5 articles (01/2011 - 01/2004)
7. Zhang, Yun Po: 5 articles (01/2011 - 01/2004)
8. He, Tao: 4 articles (08/2020 - 01/2011)
9. Delgado, E: 4 articles (01/2015 - 01/2009)
10. Amini, Pejmon: 3 articles (12/2021 - 02/2018)

Related Diseases

1. Dentin Sensitivity
03/01/2018 - "To examine dentin hypersensitivity (DH) at multiple time points over a 14-day period in participants who brushed twice daily with a 0.454% SnF2 dentifrice (Test) compared to a 0.76% sodium monofluorophosphate dentifrice with no known anti-sensitivity properties (Control). "
11/01/2019 - "To evaluate effects of a 0.454% stannous fluoride test toothpaste on dentine hypersensitivity (DH) applied by fingertip, then 3 days' brushing, versus a sodium monofluorophosphate-based control. "
02/18/2011 - "The dentine hypersensitivity was evaluated by a subject self-perceived short, sharp pain in visual analogue scale (VAS) in response to a blast of cold air from a triple syringe administered to a tooth surface in 1 cm. Test toothpastes, containing 5.53% potassium citrate and 0.76% sodium monofluorophosphate, and control toothpastes, containing only 0.76% sodium monofluorophosphate were delivered to the study subjects in the test and control group respectively. "
08/01/2015 - "To compare the efficacy of an anhydrous dentifrice containing 0.454% w/w stannous fluoride and a negative control dentifrice containing 1,000 ppm fluoride, as sodium monofluorophosphate, at reducing dentin hypersensitivity over 8 weeks with twice-daily brushing. "
03/01/2013 - "To compare the efficacy of a 0.454% w/w stannous fluoride containing anhydrous dentifrice and a negative control dentifrice containing 1,000 ppm fluoride (as sodium monofluorophosphate) at reducing dentin hypersensitivity over an 8-week period, following twice daily brushing. "
2. Gingivitis
11/01/1976 - "The aims of the present study were (1) to analyze the separate effects on plaque, caries, and gingivitis of several measures (oral hygiene instruction, professional tooth cleaning with mechanical instruments, topical application of sodium monofluorophosphate - MFP) which have been incorporated in a prophylactic treatment program, described by AXELSSON & LINDHE1, and (2) to prevent caries and gingivitis by applying the combined treatment but replacing the professional mechanical tooth cleaning with chemical cleaning using a chlorhexidine-containing gel. "
12/01/2021 - "This examiner-blind, stratified, parallel study aimed to evaluate the anti-gingivitis efficacy of a non-aqueous (anhydrous) 0.454% w/w stannous fluoride toothpaste ('Test') versus a sodium monofluorophosphate toothpaste ('Control') in people with clinically-confirmed mild-moderate gingivitis. "
11/02/2023 - "Randomized, double-blinded, controlled clinical studies meeting the following predefined selection criteria were identified: 1) published and unpublished gingivitis clinical trials conducted from 1995 to 2022 comparing efficacy of 0.454% SnF2 dentifrices to negative controls (sodium fluoride or sodium monofluorophosphate dentifrice) and 2) studies with a 3-mo assessment and at least a 1- or 6-mo assessment. "
01/15/2020 - "A 2-month-long comparative clinical study of toothpaste containing 1450 ppm sodium monofluorophosphate and xylitol (control, 15 patients) and toothpaste additionally containing extracts of the medicinal herbs (experiment, 35 patients) was performed on patients with gingivitis and the initial stage of periodontitis. "
04/01/2018 - "To evaluate and compare gingival health, as measured by a bleeding index (BI), a modified gingival index (MGI), number of bleeding sites, and blood in expectorate following twice daily use of a non-aqueous 0.454% weight/weight (w/w) stannous fluoride dentifrice ('Test dentifrice') compared to a sodium monofluorophosphate (SMFP) dentifrice (' Negative Control') over 12 weeks, in subjects with moderate gingivitis and gingival bleeding following tooth brushing. "
3. Hypersensitivity (Allergy)
4. Dental Calculus
01/01/1998 - "The objective of this double-blind clinical study, conducted following the Volpe-Manhold design for studies of dental calculus, was to investigate the efficacy of a dentifrice containing 2% zinc citrate and 0.76% sodium monofluorophosphate in a silica base (zinc citrate dentifrice) as compared to a control dentifrice containing 0.76% sodium monofluorophosphate in a silica base (control dentifrice). "
01/01/2015 - "To assess the efficacy of an experimental 1450 ppm fluoride as sodium monofluorophosphate (SMFP)/zinc-based dentifrice (Test), a clinically proven 1450 ppm fluoride as SMFP/zinc-based dentifrice (Positive Control), and a 1000 ppm fluoride as SMFP and 450 ppm fluoride as sodium fluoride (NaF) dentifrice (Negative Control) in delivering 12-hour anti-tartar benefits as measured by calcium buildup after a single product brushing. "
01/01/1998 - "In the second organoleptic study, a dentifrice containing 65% baking soda demonstrated significantly greater ability to reduce breath odor than a standard sodium fluoride/silica tartar control dentifrice, but did not differ significantly from a standard dentifrice containing 0.76% sodium monofluorophosphate in a dicalcium phosphate dihydrate base. "
01/01/1994 - "The effect of a dentifrice containing 5.0% potassium nitrate, 1.3% soluble pyrophosphate, 1.5% PVM/MA copolymer, and 0.243% sodium fluoride in a silica base (Sensitive/Tartar Control) on dentinal hypersensitivity over a twelve-week period was compared to a commercially available dentifrice containing 5% potassium nitrate and 0.76% sodium monofluorophosphate in a dicalcium phosphate dihydrate base (Sensodyne-F). "
5. Postmenopausal Osteoporosis

Related Drugs and Biologics

1. Dentifrices (Dentifrice)
2. Fluorides
3. Sodium Fluoride (Ossin)
4. Arginine (L-Arginine)
5. Calcium Carbonate (Limestone)
6. Toothpastes
7. Tin Fluorides (Floran)
8. Calcium
9. Silicon Dioxide (Silica)
10. Potassium Chloride

Related Therapies and Procedures

1. Hormone Replacement Therapy (Therapy, Hormone Replacement)
2. Toothbrushing
3. Oral Hygiene (Dental Hygiene)
4. Fluoride Treatment
5. Therapeutics